Chest
Clinical InvestigationsASTHMARacial Differences in Physiologic Parameters Related to Asthma Among Middle-class Children
Section snippets
Recruitment
The data used in these analyses were from a combination of two study groups of children residing in suburban Detroit, MI: the Childhood Allergy Study (CAS) and Southfield Childhood Allergy Study (SCAS). The selection of the CAS has been previously described.17 Briefly, all pregnant women ≥ 18 years old belonging to the Health Alliance Plan health maintenance organization and residing in a defined group of zip codes encompassing the northern middle-class suburbs of Detroit, MI, were eligible if
Characteristics of the Study Population
Table 1 shows the enrollment and losses for the individual groups before arriving at the final combined population of 569 (79 AA and 490 EA children). All children were between 6 and 8 years of age at the time of the clinical evaluation. For the CAS group, 601 parents were contacted, of which 80.5% made a clinic visit (Table 1). After applying exclusion criteria for this study, 471 participants (78.4%) were available for analysis. For the SCAS group, a total of 170 children were contacted,
Discussion
Our objective was to investigate possible racial variations in immunologic and physiologic parameters associated with asthma severity in young children. In this analysis, we found that the association of serum IgE and methacholine reactivity, widely accepted as a positive one in asthma patients, was not observed in AA subjects. We did find this relationship in the EA children. To our knowledge, this apparent racial difference in the relationship between total IgE and airway reactivity has not
ACKNOWLEDGMENT
We would like to acknowledge the clinical contributions of Dr. Tonya Corbin to this research.
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This study was funded by a Fellowship from the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Immunologic Diseases of the National Institutes of Health (Grant AI24156), and by the Henry Ford Health System Medical Treatment Effectiveness Programs (MEDTEP) Research Center on Minority Populations, through Grant U01 HS07386 from the Agency for Health Care Policy and Research.