Chest
Clinical InvestigationsInfectionPulmonary Fungal Infection: Emphasis on Microbiological Spectra, Patient Outcome, and Prognostic Factors
Section snippets
Materials and Methods
The medical records of consecutive patients with diagnoses of pulmonary fungal infection treated at National Taiwan University Hospital during the period of January 1988 through December 1997 were reviewed. The inclusion of a patient required that the following criteria were met: obvious lung lesion shown on chest radiography and at least one of the following: (1) identification of fungi in biopsy specimens obtained from open thoracotomy, thoracoscopy, transbronchial lung biopsy, or
Clinical Characteristics
From January 1988 to December 1997, medical and microbiological records of 187 patients with pulmonary fungal infection were reviewed. Of these, 140 patients fulfilled the inclusion criteria by various diagnostic methods (Table 1). There were 74 patients included by pathologic examinations of biopsy specimens. Fifty-eight patients had fungi isolated from biopsy specimens, aspirated fluids, pleural effusions, or blood. Three patients had cryptococci confirmed by microscopic examinations of
Discussion
There has been an increasing incidence of pulmonary fungal infection at our hospital in the past decade. A large portion was acquired from sources other than the hospital. The most frequently encountered pathogens were Aspergillus species, followed by Cryptococcus species and Candida species. The major prognostic factors of acute invasive fungal infection were the source of fungal infection and the occurrence of respiratory failure.
Previous literature was concerned mostly with invasive and
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2022, European Journal of Internal MedicineCitation Excerpt :Our findings suggest that more aggressive source control and preventing nosocomial infections were interventions that can improve survival. Chen et al. reported that “hospital infection” is an important prognostic factor among invasive pulmonary fungal infections [22]. Whereas, our study is the first large-scale study to reveal HAI as a risk factor for poor outcome among ROCM patients.
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Manusript received August 1, 2000; revision accepted February 14, 2001.