Chest
Clinical Investigations in Critical CarePrognostic Value of the Indocyanine Green Plasma Disappearance Rate in Critically Ill Patients
Section snippets
Materials and Methods
We retrospectively analyzed data from 336 critically ill patients (120 female and 216 male; age range, 10 to 89 years; mean ŷ SD age, 53 ŷ 19 years) who were treated in our ICU between 1996 and 2000. Admission diagnosis was sepsis/septic shock according to the criteria of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference10 (n = 166), ARDS (n = 43), severe head trauma (n = 45), hemorrhagic shock (n = 28), and intracranial hemorrhage (n = 54).
Results
Demographic data and patients’ characteristics are summarized in Table 1. In our results, the ICG-PDR was significantly lower in nonsurvivors than in survivors (mean, 8.0 ŷ 6.7%/min; median, 6.4%/min; vs mean, 16.7 ŷ 7.6%/min; median, 16.5%/min, respectively [p < 0.001]; Fig 1). Patients with sepsis (n = 166) had a significantly lower ICG-PDR than those without sepsis (n = 170): median, 6.9%/min vs 16.1%/min, respectively (p < 0.001). By separating several ranges of lowest ICG-PDRs, the
Discussion
There is evidence from several previous studies14,15,16,17 that have analyzed a small number of patients with specific disorders that the ICG-PDR can be used as a prognostic tool. Previous studies have not used a fiberoptic system that enables measurement of the ICG-PDR at the bedside. We therefore tried to assess the value of the ICG-PDR in a wider variety of critically ill patients. In our study, the ICG-PDR as a marker of liver perfusion and function was found to be a good predictor of
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