Chest
Clinical InvestigationsSARCOIDOSISHealth-Related Quality of Life of Persons With Sarcoidosis
Section snippets
Subjects
We recruited all consecutive outpatients with sarcoidosis presenting between March and July 2002 to one of three university medical center outpatient pulmonary clinics (ie, University of North Carolina at Chapel Hill, Medical University of South Carolina, and East Carolina University) for inclusion in this study. Patients were excluded from the study if they were < 18 years of age, were organ transplant recipients, had active cancer, were not fluent English speakers, or had cognitive or reading
Patients
A total of 120 patients were enrolled in the study, although we excluded data from 9 patients with incomplete questionnaires. Table 1 demonstrates that the median patient age was 45 years (age range, 22 to 73 years). Most patients were female (78%), African-American (80%), and high school graduates (66%). Nearly all patients had pulmonary involvement (94%), although 61% had additional extrapulmonary disease. The median number of organs involved was two (range, one to five organs). Participants
Discussion
In the largest US study to date that has been designed specifically to assess the HRQL of sarcoidosis patients, we found significant decrements in physical, emotional, social, and role functioning of stable outpatients compared to historical population control subjects, using validated generic, respiratory-specific, and mental health questionnaires that were as prominent as those reported among survivors of ARDS,30 patients with symptomatic AIDS,40 persons with end-stage renal disease,41 and
ACKNOWLEDGMENT
The authors thank Amelia Anderson, Julie Montenegro, Jeanie Mascarella, Cathey Kaelin, Tim Carey, Sue Tolleson-Rinehart, Donald Pathman, the University of North Carolina-Chapel Hill National Research Service Award clinical research group, and the patients who participated for their assistance with this study.
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This study was supported by a Public Health Outcomes grant from the University of North Carolina at Chapel Hill School of Public Health.