Chest
Clinical InvestigationsSputum Cathelicidin, Urokinase Plasminogen Activation System Components, and Cytokines Discriminate Cystic Fibrosis, COPD, and Asthma Inflammation
Section snippets
Subjects
We recruited 28 patients with CF (age, 12 to 50 years) followed up at the CF Center clinic at Stanford University Medical Center. CF diagnoses in all patients were made by positive (> 60 mEq/L) pilocarpine iontophoresis sweat test results, with homozygous or compound heterozygous for ΔF508 CF transmembrane conductance regulator mutations. All patients had chronic infection with Pseudomonas aeruginosa by serial sputum culture and were in stable clinical condition (no pulmonary exacerbation
Subject Groups
The CF patients (17 women and 11 men) were generally young adults (mean ± SD age, 23.7 ± 11.1 years) with well-preserved pulmonary function (mean ± SD FEV1, 74.0 ± 17.4% predicted). The patients with COPD (24 women and 50 men) were, as expected, older (59.2 ± 9.9 years) with generally greater airflow obstruction (FEV1, 54.6 ± 13.7% predicted). The patients with asthma (19 women and 15 men) were intermediate between these other groups in age (47.4 ± 13.9 years) and airflow obstruction (FEV1,
Discussion
Research123031 has focused on the role of deranged aspects of innate immunity in the pathobiology of chronic inflammatory airways diseases such as CF, asthma, and COPD. In the present study, we were interested in aspects of the innate immune response in CF, in particular the following: (1) the role of the uPA system and the antimicrobial cathelicidin CAP18 that have not received much attention, and (2) how any abnormalities in CF compared to COPD and asthma as well as healthy persons. In order
Acknowledgment
We thank Theresa Chen for helping with Chinese-English translation.
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Cited by (0)
This study was funded by the Ross Mosier and Berger Raynolds Funds.
Drs. Moss, Ishizaka, and Kirikae have assigned entire right, title, and interest in the CAP18 immunoassay described here to Seikagaku Corporation, Tokyo, Japan.
Reproduction of this article is prohibited without written permission from the American College of Chest Physicians (www.chestjournal.org/misc/reprints.shtml).