Chest
Clinical InvestigationsClinical Dysautonomia in Patients with Bronchial Asthma: Study with Seven Autonomic Function Tests
Section snippets
Subjects and Methods
The study included 50 patients with bronchial asthma and 20 healthy volunteers after their written consent was obtained. All the patients had history and clinical features of bronchial asthma as defined by the American Thoracic Society.17
The following criteria were followed while selecting the patients: duration of asthma more than two years, with at least two acute asthmatic exacerbations in any year; patient's age between 15 and 50 years; should not have received any drug modulating the
Results
Of the 50 asthmatic patients studied, nine were atopic and 41 nonatopic. The proportion of men to women control subjects and asthmatic patients was 1.86:1 and 1.94:1, respectively. The mean age of asthmatic patients was 31.75±10.43 years and that of control subjects, 33.22±10.83 years, thus excluding the variables in autonomic tone occurring with age. The duration of asthma in patients ranged from 2 to 30 years. Thirty one patients had disease for ten years, seven had disease for more than 20
Discussion
It has been well documented that dysautonomia in asthmatic patients is generalized.4 Since the rate of discharge of sinoatrial node is under vagal control, the possibility exists that an alteration in autonomic control in airway caliber may be reflected by a parallel change in control of the heart rate,7 and the blood pressure responses mediated by sympathetic nervous system may reflect the altered sympathetic airway tone.
In the preview of vagal hypertonia in asthma,1, 25 alteration in the
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Cited by (28)
Asthmatic subjects stratification using autonomic nervous system information
2021, Biomedical Signal Processing and ControlCitation Excerpt :Since broncho-constriction and bronchomotor tone control are mainly mediated by the vagal pathway of the ANS [13,14], and given the role of the neural control as a modulator of airway inflammation [15], the suspicion that an altered ANS functioning could be an important factor in the pathogenesis of asthma has received widespread research attention for decades. In this context, heart rate variability (HRV) analysis has raised as a feasible option, and has been employed for the characterization of ANS activity in asthmatic children [16–18] and adults [19–21], revealing an increased vagal dominance in response to autonomic tests [16,19,21] or during sleep [17,18,20]. Moreover, the study of asthmatic subjects classified based on their asthma control suggests a decreased HRV in subjects with uncontrolled asthma [22,23].
Thiamin and protein folding
2019, Medical HypothesesControl of the lungs via the human brain using neurosurgery
2014, Progress in Brain ResearchCitation Excerpt :Barnes, 1995). Autonomic dysfunction is seen in asthma in the form of parasympathetic hyper-responsiveness (Shah et al., 1990) with reduced low frequency component of heart rate variability (Garrard et al., 1992) compared to healthy controls. It is promising that the only patient studied whose baseline FEV1/FVC ratio was low, 67%, signifying airway obstruction, demonstrated an improved ratio of 72% with PAG stimulation.
Neuropeptide Y polymorphism increases the risk for asthma in overweight subjects; protection from atherosclerosis in asthmatic subjects - The cardiovascular risk in young Finns study
2012, NeuropeptidesCitation Excerpt :Asthma, like atherosclerosis, is a chronic inflammatory disease. Airway inflammation and hyperresponsiveness are characteristic features of asthma, and many studies suggest that asthma is associated with increased parasympathetic responsiveness (Jartti et al., 1996; Shah et al., 1990; Jartti, 2001). Asthma and atopic diseases are associated mainly with enhanced Th2-type inflammatory responses instead of Th1-type (Umetsu and DeKruyff, 2006; Finn and Bigby, 2009).
Autonomic nervous system dysfunction and their relationship with disease severity in children with atopic asthma
2012, Respiratory Physiology and NeurobiologyAutonomic dysfunction and clinical severity of disease in children with allergic rhinitis
2012, International Journal of Pediatric OtorhinolaryngologyCitation Excerpt :In a study by Kaliner et al., all allergic subjects showed abnormal beta-adrenergic hypo-reactivity and cholinergic hypersensitivity, whereas allergic asthma was solely associated with excessive alpha-adrenergic responsiveness [26]. In many studies in adults but not in children increased PSN tone has been associated with clinical asthma or the worsening of asthma [27,28]. In our study, RRIV was used as the electrophysiological test to evaluate the PNS.
Manuscript received January 8; revision accepted May 15.