Abstract
Our study evaluated the relationship between the pathologic changes associated with atherosclerosis, as primarily represented by postprandial remnant-like lipoproteins and carotid intima-media thickness (IMT), in type 2 diabetic patients. Meal tolerance tests (MTT) were performed in 68 patients with type 2 diabetes. The subjects were divided by pre-meal and 2-h postprandial triglyceride (TG) levels into the normotriglyceridemia (NTG) group; the postprandial hypertriglyceridemia (PHTG) group; and the fasting hypertriglyceridemia (FHTG) group. HOMA-R values were significantly higher in the FHTG group than in the NTG group, with the plasma pre-heparin LPL mass and serum adiponectin levels in the FHTG and PHTG groups significantly lower than in the NTG group. One- and two hour postprandial RLP-TG levels were significantly higher in the PHTG group than in the NTG group, while there was no significant difference in postprandial glucose levels between the two groups. The IMT values were significantly higher in both the FHTG and PHTG groups than in the NTG group. Logistics regression analysis of the 1-and 2-h RLP-TG values using IMT as an induced variable showed the odds ratio for high IMT values to be 5.17 (p<0.05) for the 1-h RLP-TG values and 3.01 (p=0.105) for the 2-h RLP-TG values. Our study results suggest that delayed TG metabolism leading to the retention of remnants in type 2 diabetic patients appears to be closely associated with atherosclerosis, and that postprandial hyperlipidemia is an independent risk factor for the early onset of atherosclerosis.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ceriello, A., Taboga, C., Tonutti, L., et al. (2002). Circulation 106, 1211–1218.
Kasama, T., Yoshino, G., Iwatani, I., et al. (1987). Atherosclerosis 63, 263–266.
Watanabe, N., Taniguchi, T., Taketoh, H., et al. (1999). Diabetes Care 22, 152–156.
Iwai, M., Yoshino, G., Matsushita, M., et al. (1990). Diabetes Care 13, 792–796.
Tanaka, A., Tomie, N., Nakano, T., et al. (1998). Clin. Chim. Acta 275, 43–52.
Ai, M., Tanaka, A., Ogita, K., et al. (2000). J. Clin. Endocrinol. Metab. 85, 3557–3560.
Ai, M., Tanaka, A., Ogita, K., et al. (2001). J. Am. Coll. Cardiol. 38, 1628–1632.
McNamara, J. R., Shah, P. K., Nakajima, K., et al. (2001). Atherosclerosis 154, 229–236.
Kugiyama, K., Doi, H., Takazoe, K., et al. (1999). Circulation 99, 2858–2860.
Nakajima, K., Saito, T., Tamura, A., et al. (1993). Clin. Chim. Acta 223, 53–71.
Olivecrona, G., Hultin, M., Savonen, R., et al. (1995). In: Atherosclerosis X. Woodford, F. P., Davignon, J., and Sniderman, A. (eds.). Elsevier, New York, pp. 250–253.
Watanabe, H., Miyashita, Y., Murano, T., Hiroh, Y., Itoh, Y., and Shirai, K. (1999). Atherosclerosis 145, 45–50.
Krapp, A., Zhang, H., Ginzinger, D., et al. (1995). J. Lipid Res. 35, 2363–2374.
Jacqueline, E. R., Howard, G., Craven, T. E., Bond, M. G., Hagaman, A. P., and Crouse, J. R. III. (1992). Stroke 23, 823–828.
Karpe, F., de Faire, U., Mercuri, M., Bond, M. G., Hellénius, M.-L., and Hamsten, A. (1998). Atherosclerosis 141, 307–314.
Boquist, S., Ruotolo, G., Tang, R., et al. (1999). Circulation 100, 723–728.
Teno, S., Uto, Y., Nagashima, H., et al. (2000). Diabetes Care 23, 1401–1406.
Chen, X., Tian, H., and Liu, R. (2003). Chin. Med. J. 116, 1933–1935.
Iso, H., Naito, Y., Sato, S., et al. (2001). Am. J. Epidemiol. 153, 490–499.
Karpe, F., Hellenius, M., and Hamsten, A. (1999). Metabolism 48, 301–307.
Guerci, B., Verges, B., Durlach, V., Hadjadj, S., Drouin, P., and Paul, J. (2000). Int. J. Obesity 24, 468–478.
Schrezenmeir, J., Keppler, I., Fenselau, S., et al. (1993). Ann. NY Acad. Sci. 683, 302–314.
Uiterwaal, C. S. P. M., Grobbee, D. E., Witteman, J. C. M., et al. (1994). Ann. Intern. Med. 121, 576–583.
Reznik, Y., Pousse, P., Herrou, M., et al. (1996). Metabolism 45, 63–71.
Jovinge, S., Hamsten, A., Tornvall, P., et al. (1998). Metabolism 47, 113–118.
Mohrschladt, M. F., Weverling-Rijnsburger, A. W., de Man F. H. et al. (2000). Atherosclerosis 148, 413–419.
Furukawa, S., Fujita, T., Shimabukuro, M., et al. (2004). J. Clin. Invest. 114, 1752–1761.
Ouchi, N., Kihara, S., Arita, Y., et al. (1999). Circulation 100, 2473–2476.
Ouchi, N., Kihara, S., Arita, Y., et al. (2001). Circulation 103, 1057–1063.
Arita, Y., Kihara, S., Ouchi, N., et al. (2002). Circulation 105, 2893–2898.
DECODE Study Group. (1999). Lancet 354, 617.
Tominaga, M., Eguchi, H., Manaka, H., Igarashi, K., Kato, T., and Sekikawa, A. (1999). Diabetes Care 22, 920–924.
Hanefeld, M., Koehler, C., Henkel, E., Fuecker, K., Schaper, F., and Temelkova-Kurktschiev, T. (2000). Diabet. Med. 17, 835–840.
Hanefeld, M., Fischer, S., Julius, U., et al. (1996). Diabetologia 39, 1577–1583.
Ogawa, S., Takeuchi, K., Sugimura, K., et al. (2000). Metabolism 49, 331–334.
Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., and Turner, R. C. (1985). Diabetologia 28, 412–419.
Kobayashi, J., Hashimoto, H., Fukamachi, I., et al. (1993). Clin. Chim. Acta 16, 113–123.
Yoshimizu, T., Nakamura, T., Yamane, M., et al. (1999). Radiology 211, 283–286.
Pionoli, P., Tremoli, E., Poli, A., Oreste, P., and Paoletti, R. (1986). Circulation 74, 1399–1406.
Mercuri, M., Tang, R., Phillips, R. M., and Bond, M. G. (1996). Blood Press 5(Suppl. 4), 20–23.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Mori, Y., Itoh, Y., Komiya, H. et al. Association between postprandial remnant-like particle triglyceride (RLP-TG) levels and carotid intima-media thickness (IMT) in Japanese patients with type 2 diabetes. Endocr 28, 157–163 (2005). https://doi.org/10.1385/ENDO:28:2:157
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1385/ENDO:28:2:157