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Handling of thyroid follicular patterned lesions

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Abstract

A novel scheme for the classification of well-differentiated thyroid tumors composed of follicular cells and having a follicular pattern of growth is presented. In addition to the two conventional categories, i.e., adenoma and carcinoma, this scheme includes a group of tumors “of uncertain malignant potential.”

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References

  1. Baloch ZW, LiVolsi VA. Intravascular Kaposi’s-like spindle cell proliferation of the capsular vessels of follicular-derived thyroid carcinomas. Mod Pathol 11:995–998, 1998.

    PubMed  CAS  Google Scholar 

  2. Baloch ZW, LiVolsi VA. Follicular-patterned lesions of the thyroid. The bane of the pathologist, Am J Clin Pathol 117:143–150, 2002.

    Article  PubMed  Google Scholar 

  3. Bell CD, Coire C, Treger T, Volpe R, Baumal R, Fornasier VL. The “dark nucleus” and disruptions of follicular architecture: possible new histological aids for the diagnosis of the follicular variant of papillary carcinoma of the thyroid. Histopathology 39:33–42, 2001.

    Article  PubMed  CAS  Google Scholar 

  4. Chan JCK. Strict criteria should be applied in the diagnosis of encapsulated follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 117:16–18, 2002.

    Article  PubMed  Google Scholar 

  5. Collini P, Sampietro G, Rosai J, Pilotti S. Minimally invasive (encapsulated) follicular carcinoma of the thyroid gland is the low-risk counterpart of widely invasive follicular carcinoma but not of insular carcinoma. Virchows Arch 442:71–76, 2003.

    PubMed  Google Scholar 

  6. Evans HL. Follicular neoplasms of the thyroid. A study of 44 cases followed for a minimum of 10 years, with emphasis on differential diagnosis. Cancer 54:535–540, 1984.

    Article  PubMed  CAS  Google Scholar 

  7. Fonseca E, Sobrinho-Simões M. Diagnostic problems in differentiated carcinoma of the thyroid. Pathol Res Pract 191:318–331, 1995.

    PubMed  CAS  Google Scholar 

  8. Fransilla KO, Ackerman LC, Brown CL, Hedinger CE. Follicular carcinoma. Sem Diagn Pathol 2:101–122, 1985.

    Google Scholar 

  9. Fusco A, Chiappetta G, Hi P, et al. Assessment of RET/PTC oncogene activation and clonality in thyroid nodules with incomplete morphological evidence of papillary carcinoma: a search for the early precursor of papillary cancer. Am J Pathol 160:2157–2167, 2002.

    PubMed  CAS  Google Scholar 

  10. González-Cámpora R, Montero C, MarinLacave J, Galera H. Demonstration of vascular endothelium in thyroid carcinomas using Ulex europaeus I agglutinin. Histopathology 10:261–266, 1986.

    Article  PubMed  Google Scholar 

  11. Harach HR, Jasani B, Williams ED. Factor VIII as a marker of endothelial cells in follicular carcinoma of the thyroid. J Clin Pathol 36:1050–1054, 1983.

    PubMed  CAS  Google Scholar 

  12. Heffess CS, Thompson LD. Minimally invasive follicular thyroid carcinoma. Endocr Pathol 12:417–422, 2001.

    Article  PubMed  CAS  Google Scholar 

  13. Hirokawa M, Carney JA, Goellner JE, et al. Observer variation of encapsulated follicular lesions of the thyroid gland. Am J Surg Pathol 16:1508–1514, 2002.

    Article  Google Scholar 

  14. Lang W, Choritz H, Hundeshagen H. Risk factors in follicular thyroid carcinomas. A retrospective follow-up study covering a 14-year period with emphasis on morphologic findings. Am J Surg Pathol 10:246–255, 1986.

    Article  PubMed  CAS  Google Scholar 

  15. Renshaw AA, Gould EW. Why there is the tendency to “overdiagnose” the follicular variant of papillary thyroid carcinoma. Am J Clin Pathol 117:19–21, 2002.

    Article  PubMed  Google Scholar 

  16. Stephenson TJ, Griffiths DWR, Mills PM. Comparison of Ulex europaeus I lectin binding and factor VIII-antigen as markers of vascular endothelium in follicular carcinoma of the thyroid. Histopathology 10:251–260, 1986.

    Article  PubMed  CAS  Google Scholar 

  17. Tsell LL, Chan I, Chan JK. Capsular intravascular endothelial hyperplasia: a peculiar form of vasoproliferative lesion associated with thyroid carcinoma. Histopathology 39:463–468, 2001.

    Article  Google Scholar 

  18. Yamashina M. Follicular neoplasms of the thyroid. Total circumferential evaluation of the fibrous capsule. Am J Surg Pathol 16:392–400, 1992.

    Article  PubMed  CAS  Google Scholar 

  19. Williams ED (on behalf of the Chernobyl Pathologists Group). Two proposals regarding the terminology of thyroid tumors. Int J Surg Pathol 8:181–183, 2000.

    PubMed  Google Scholar 

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Rosai, J. Handling of thyroid follicular patterned lesions. Endocr Pathol 16, 279–283 (2005). https://doi.org/10.1385/EP:16:4:279

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