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Role of DJ-1 in Parkinson's disease

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An Erratum to this article was published on 01 March 2007

Abstract

Parkinson's disease (PD), one of the most common neurodegenerative diseases, is a multifactorial disease caused by both genetic and environmental factors. Although most patients suffering from PD have a sporadic disease, several genetic causes have been identified in recent years, including α-synuclein, parkin, PINK1, dardarm (LRRK2), and DJ-1. DJ-1 deletions and point mutations have been found worldwide, and loss of functional protein was shown to cause autosomal recessive PD. Moreover, DJ-1 immunoreactive inclusions are found in other α-synucleopathies and tauopathies, indicating that different neurodegenerative diseases might share a common mechanism in which DJ-1 might play a key role. The function of DJ-1 is still unknown; however, it is associated with various cellular processes, including response to oxidative stress, cellular transformation, RNA-binding, androgen-receptor signaling, spermatogenesis, and fertilization. This article reviews the current knowledge on DJ-1, focusing on its importance in the pathogenesis of PD.

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Authors and Affiliations

  1. Laboratory of Neuroscience and Department of Neurology, FMRC, Rabin Medical Center, Tel Aviv University, Israel

    Nirit Lev, Debby Ickowicz, Eldad Melamed & Daniel Offen

  2. Department of Neurology, University of Belgrade, Serbia and Montenegro

    Dusan Roncevich

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  1. Nirit Lev
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Correspondence to Nirit Lev.

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An erratum to this article is available at http://dx.doi.org/10.1385/JMN:31:03:307.

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Lev, N., Roncevich, D., Ickowicz, D. et al. Role of DJ-1 in Parkinson's disease. J Mol Neurosci 29, 215–225 (2006). https://doi.org/10.1385/JMN:29:3:215

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