Abstract
Langerhans cell sarcoma (LCS) is a neoplastic proliferation of Langerhans cells that occurs in lymph nodes, liver, skin, spleen, lung, and bone. We report a case of LCS in a 47-year-old man with a 6-month history of scalp mass and cervical lym-phadenopathy. Clinical and pathologic data were available.A histologic examination demonstrated a proliferation of cells with malignant cytologic features. Because of its poorly differentiated morphologic features, hematologic and nonhematologic entities were ruled out by immunohistochemical screening with a broad panel of antibodies. Ultrastructural studies demonstrating Birbeck granules and consistent expression of CD1a, S-100 protein, and langerin by immunohistochemistry were helpful in identifying the Langerhans cell origin. Int J Hematol. 2007;85:116-120. doi: 10.1532/IJH97.NA0604
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Bohn, O.L., Ruiz-Argüelles, G., Navarro, L. et al. Cutaneous langerhans cell sarcoma: a case report and review of the literature. Int J Hematol 85, 116–120 (2007). https://doi.org/10.1532/IJH97.NA0604
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DOI: https://doi.org/10.1532/IJH97.NA0604