Library Subscription: Guest
Critical Reviews™ in Immunology

Published 6 issues per year

ISSN Print: 1040-8401

ISSN Online: 2162-6472

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) IF: 1.3 To calculate the five year Impact Factor, citations are counted in 2017 to the previous five years and divided by the source items published in the previous five years. 2017 Journal Citation Reports (Clarivate Analytics, 2018) 5-Year IF: 2.6 The Eigenfactor score, developed by Jevin West and Carl Bergstrom at the University of Washington, is a rating of the total importance of a scientific journal. Journals are rated according to the number of incoming citations, with citations from highly ranked journals weighted to make a larger contribution to the eigenfactor than those from poorly ranked journals. Eigenfactor: 0.00079 The Journal Citation Indicator (JCI) is a single measurement of the field-normalized citation impact of journals in the Web of Science Core Collection across disciplines. The key words here are that the metric is normalized and cross-disciplinary. JCI: 0.24 SJR: 0.429 SNIP: 0.287 CiteScore™:: 2.7 H-Index: 81

Indexed in

Gain Access(open in a new tab)
More
Purchase $35.00(open in a new tab) Check subscription Download MARC record(open in a new tab) Get Permissions(open in a new tab)

Immune-Potentiating Effects of the Chemotherapeutic Drug Cyclophosphamide

Volume 28, Issue 2, 2008, pp. 109-126
DOI: 10.1615/CritRevImmunol.v28.i2.20
Get accessGet access
Sven Brode
Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK
Anne Cooke
Department of Pathology, University of Cambridge, Cambridge CB2 1QP, UK

ABSTRACT

Cyclophosphamide (CTX) is an alkylating cytotoxic drug that primarily affects proliferating lymphocytes. CTX has been extensively used as a chemotherapeutic and disease-modifying agent against certain solid tumors, lymphomas, and some autoimmune conditions. Depending on its dose and timing of administration, CTX can also enhance immune responses. These opposing immune functions of CTX have been investigated in numerous animal models and recent clinical studies. Administration of CTX augments delayed type 1 hypersensitivity (DTH) reactions, can precipitate type 1 diabetes, and boosts antitumor responses in both vaccination and adoptive cell transfer models. Although the mechanisms by which CTX elicits these effects are not fully understood, CTX treatment has a differential effect on lymphocyte compartments, rapidly depleting B and T cells. This is followed by a recovery phase characterized by extensive proliferation and bone marrow mobilization. The proposed underlying mechanisms of augmentation of immune responses include the facilitation of homing and homeostatic proliferation by the creation of space, the skewing of Th2/Th1 responses due to the “cytokine storm” during the recovery phase, and the removal or inhibition of a suppressor cell population. With the identification of naturally occurring and peripheral regulatory T cells, recent studies have re-evaluated these hypotheses and suggest that CTX inhibits the function of Foxp3+ regulatory T cells. In this review, we critically evaluate relevant historical and recent data on CTX-mediated immunomodulation and discuss the resulting implications for immunotherapy.

CITED BY

  1. Legrand Jean-Jacques, Bouchez Caroline, Mimouni Cécile, N’Guyen Armelle, Bouchard Johanne, Ameller Thibault, Descotes Jacques, Immunotoxic effects of cyclophosphamide and cyclosporine in the dog, Journal of Immunotoxicology, 10, 1, 2013. Crossref

  2. Hirschhorn-Cymerman Daniel, Budhu Sadna, Kitano Shigehisa, Liu Cailian, Zhao Feng, Zhong Hong, Lesokhin Alexander M., Avogadri-Connors Francesca, Yuan Jianda, Li Yanyun, Houghton Alan N., Merghoub Taha, Wolchok Jedd D., Induction of tumoricidal function in CD4+ T cells is associated with concomitant memory and terminally differentiated phenotype, Journal of Experimental Medicine, 209, 11, 2012. Crossref

  3. Salem Mohamed L., Al-Khami Amir A., El-Nagaar Sabry A., Zidan Abdel-Aziz A., Al-Sharkawi Ismail M., Marcela Díaz-Montero C., Cole David J., Kinetics of rebounding of lymphoid and myeloid cells in mouse peripheral blood, spleen and bone marrow after treatment with cyclophosphamide, Cellular Immunology, 276, 1-2, 2012. Crossref

  4. Wu Tingting, Zhang Lianjun, Xu Kerui, Sun Chenming, Lei Tong, Peng Jianxia, Liu Guangwei, Wang Ruoyu, Zhao Yong, Immunosuppressive drugs on inducing Ag-specific CD4+CD25+Foxp3+ Treg cells during immune response in vivo, Transplant Immunology, 27, 1, 2012. Crossref

  5. Dou Ai-Xia, Feng Li-Li, Liu Xiao-Qian, Wang Xin, Cyclic adenosine monophosphate involvement in low-dose cyclophosphamide-reversed immune evasion in a mouse lymphoma model, Cellular & Molecular Immunology, 9, 6, 2012. Crossref

  6. Zdravkovic Nemanja, Pavlovic Sladjana, Zdravkovic Vladimir, Pejnovic Nada, Arsenijevic Nebojsa, Lukic Miodrag L., ST2 gene-deletion reveals a role of Foxp3+ regulatory T cells in diabetes modulation in BALB/c mice, Translational Research, 161, 2, 2013. Crossref

  7. Butts Charles, Murray R. Nevin, Smith Colum J., Ellis Peter M., Jasas Kevin, Maksymiuk Andrew, Goss Glenwood, Ely Guy, Beier Frank, Soulières Denis, A Multicenter Open-Label Study to Assess the Safety of a New Formulation of BLP25 Liposome Vaccine in Patients With Unresectable Stage III Non–Small-Cell Lung Cancer, Clinical Lung Cancer, 11, 6, 2010. Crossref

  8. Ding Zhi-Chun, Huang Lei, Blazar Bruce R., Yagita Hideo, Mellor Andrew L., Munn David H., Zhou Gang, Polyfunctional CD4+ T cells are essential for eradicating advanced B-cell lymphoma after chemotherapy, Blood, 120, 11, 2012. Crossref

  9. Delrieu Julien, Piau Antoine, Vellas Bruno, Drug Development and Alzheimer's Disease, in Pathy's Principles and Practice of Geriatric Medicine, 2012. Crossref

  10. Traverso Ilaria, Fenoglio Daniela, Negrini Simone, Parodi Alessia, Battaglia Florinda, Kalli Francesca, Conteduca Giuseppina, Tardito Samuele, Traverso Paolo, Indiveri Francesco, Filaci Gilberto, Cyclophosphamide inhibits the generation and function of CD8+ regulatory T cells, Human Immunology, 73, 3, 2012. Crossref

  11. Litterman Adam J, Dudek Arkadiusz Z, Largaespada David A, Alkylating chemotherapy may exert a uniquely deleterious effect upon neo-antigen-targeting anticancer vaccination, OncoImmunology, 2, 10, 2013. Crossref

  12. Huyan Xiao-Hui, Lin Ying-Ping, Gao Tao, Chen Rong-Yi, Fan Yi-Ming, Immunosuppressive effect of cyclophosphamide on white blood cells and lymphocyte subpopulations from peripheral blood of Balb/c mice, International Immunopharmacology, 11, 9, 2011. Crossref

  13. Weigert Olivia, von Spee Caroline, Undeutsch Reinmar, Kloke Lutz, Humrich Jens Y, Riemekasten Gabriela, CD4+Foxp3+ regulatory T cells prolong drug-induced disease remission in (NZBxNZW) F1 lupus mice, Arthritis Research & Therapy, 15, 1, 2013. Crossref

  14. Tsuchikawa Takahiro, Hirano Satoshi, Tanaka Eiichi, Matsumoto Joe, Kato Kentaro, Nakamura Toru, Ebihara Yuma, Shichinohe Toshiaki, Novel aspects of preoperative chemoradiation therapy improving anti-tumor immunity in pancreatic cancer, Cancer Science, 104, 5, 2013. Crossref

  15. Wu Xia, Feng Qin-Mei, Wang Ying, Shi Jun, Ge Hai-Liang, Di Wen, The immunologic aspects in advanced ovarian cancer patients treated with paclitaxel and carboplatin chemotherapy, Cancer Immunology, Immunotherapy, 59, 2, 2010. Crossref

  16. Piau Antoine, Nourhashémi F., Hein C., Caillaud C., Vellas B., Progress in the development of new drugs in Alzheimer’s disease, The journal of nutrition, health & aging, 15, 1, 2011. Crossref

  17. Fort Madeline M., Narayanan Padma K., Manipulation of Regulatory T-Cell Function by Immunomodulators: A Boon or a Curse?, Toxicological Sciences, 117, 2, 2010. Crossref

  18. Sharabi Amir, Ghera Nechama Haran, , 107, 2010. Crossref

  19. Całkosiński Ireneusz, Rosińczuk-Tonderys Joanna, Dzierzba Katarzyna, Bazan Justyna, Całkosińska Monika, Majda Jacek, Dobrzyński Maciej, Bronowicka-Szydełko Agnieszka, Mechlorethamine (NTG) effects on the erythrocytic and leukocytic blood parameters during experimentally induced pleuritis in rats, Pharmacological Reports, 64, 3, 2012. Crossref

  20. Salem Mohamed Labib, Cole David J., Dendritic cell recovery post-lymphodepletion: a potential mechanism for anti-cancer adoptive T cell therapy and vaccination, Cancer Immunology, Immunotherapy, 59, 3, 2010. Crossref

  21. Liu Pu, Jaffar Jade, Hellstrom Ingegerd, Hellstrom Karl Erik, Administration of Cyclophosphamide Changes the Immune Profile of Tumor-bearing Mice, Journal of Immunotherapy, 33, 1, 2010. Crossref

  22. Hirschhorn-Cymerman Daniel, Rizzuto Gabrielle A., Merghoub Taha, Cohen Adam D., Avogadri Francesca, Lesokhin Alexander M., Weinberg Andrew D., Wolchok Jedd D., Houghton Alan N., OX40 engagement and chemotherapy combination provides potent antitumor immunity with concomitant regulatory T cell apoptosis, Journal of Experimental Medicine, 206, 5, 2009. Crossref

  23. Sidana Abhinav, Rodriguez Ronald, Urologic Applications of Cryo-Immunology, Korean Journal of Urology, 50, 7, 2009. Crossref

  24. Gassner Franz Josef, Weiss Lukas, Geisberger Roland, Hofbauer Josefina Piñón, Egle Alexander, Hartmann Tanja Nicole, Greil Richard, Tinhofer Inge, Fludarabine modulates composition and function of the T cell pool in patients with chronic lymphocytic leukaemia, Cancer Immunology, Immunotherapy, 60, 1, 2011. Crossref

  25. Liu W M, Fowler D W, Smith P, Dalgleish A G, Pre-treatment with chemotherapy can enhance the antigenicity and immunogenicity of tumours by promoting adaptive immune responses, British Journal of Cancer, 102, 1, 2010. Crossref

  26. Yamamura Yoshiyuki, Tsuchikawa Takahiro, Miyauchi Kengo, Takeuchi Shintaro, Wada Masataka, Kuwatani Toshihiko, Kyogoku Noriaki, Kuroda Aki, Maki Takehiro, Shichinohe Toshiaki, Hirano Satoshi, The key role of calreticulin in immunomodulation induced by chemotherapeutic agents, International Journal of Clinical Oncology, 20, 2, 2015. Crossref

  27. Saurer L., Mueller C., T cell-mediated immunoregulation in the gastrointestinal tract, Allergy, 64, 4, 2009. Crossref

  28. Herrera Zaima Mazorra, Ramos Tania Crombet, Pilot study of a novel combination of two therapeutic vaccines in advanced non-small-cell lung cancer patients, Cancer Immunology, Immunotherapy, 63, 7, 2014. Crossref

  29. Ireneusz Całkosiński, Joanna Rosińczuk-Tonderys, Katarzyna Dzierzba, Agnieszka Bronowicka-Szydełko, Ewa Seweryn, Jacek Majda, Monika Całkosińska, Andrzej Gamian, Estimation of the action of three different mechlorethamine doses on biochemical parameters during experimentally induced pleuritis in rats, Pharmacological Reports, 63, 2, 2011. Crossref

  30. Swann James W, Garden Oliver A, Novel immunotherapies for immune-mediated haemolytic anaemia in dogs and people, The Veterinary Journal, 207, 2016. Crossref

  31. Ghareeb Doaa A., Salem Mohamed L., El-Desouky Nabila, Mohamed Idrris H., Concomitant treatment with beta-glucan and G-CSF ameliorates altered biochemical indices after cyclophosphamide-induced leukopenia in mice, Biotechnology & Biotechnological Equipment, 29, 5, 2015. Crossref

  32. Thornton A.M., Regulatory T Cells, in Comprehensive Toxicology, 2010. Crossref

  33. Mkrtichyan Mikayel, Najjar Yana G., Raulfs Estella C., Abdalla Maher Y., Samara Raed, Rotem-Yehudar Rinat, Cook Larry, Khleif Samir N., Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms, European Journal of Immunology, 41, 10, 2011. Crossref

  34. Teryukova N. P., Pogodina O. N., Blinova G. I., Ivanov V. A., Immunomodulating effect of cyclophosphamide on cytotoxic activity of rat and mouse splenocytes, Cell and Tissue Biology, 5, 6, 2011. Crossref

  35. Melief Cornelis J.M., Cancer Immunotherapy by Dendritic Cells, Immunity, 29, 3, 2008. Crossref

  36. Liu Wai M., Dalgleish Angus G., The Potential Beneficial Effects of Drugs on the Immune Response to Vaccination, Seminars in Oncology, 39, 3, 2012. Crossref

  37. Lutz-Nicoladoni Christina, Wolf Dominik, Sopper Sieghart, Modulation of Immune Cell Functions by the E3 Ligase Cbl-b, Frontiers in Oncology, 5, 2015. Crossref

  38. Wu Shengli, Xu Hong, Chen Bo, Wen Yujie, Ikusika Olayemi M., Ocker Ashley, Zhao Hong, Ildstad Suzanne T., Sensitized Recipients Exhibit Accelerated but not Hyperacute Rejection of Vascularized Composite Tissue Allografts, Transplantation, 92, 6, 2011. Crossref

  39. de Guillebon E., Tartour E., Immunité antitumorale (mécanismes, immunoediting, immunosurveillance), Oncologie, 17, 9, 2015. Crossref

  40. Naito Munekazu, Sakamoto Yasuki, Terayama Hayato, Hirai Shuichi, Ning Qu, Aota Yoichi, Itoh Masahiro, Effect of unilateral testicular rupture on histopathology and germ cell delayed-type hypersensitivity in C3H/He and A/J mice, Journal of Reproductive Immunology, 81, 1, 2009. Crossref

  41. Lutz‐Nicoladoni Christina, Wallner Stephanie, Stoitzner Patrizia, Pircher Magdalena, Gruber Thomas, Wolf Anna Maria, Gastl Günther, Penninger Josef M, Baier Gottfried, Wolf Dominik, Reinforcement of cancer immunotherapy by adoptive transfer of cblb ‐deficient CD8 + T cells combined with a DC vaccine , Immunology & Cell Biology, 90, 1, 2012. Crossref

  42. Wan Zhong-xiao, Zhang Feng, Geng Qian, Wang Pei-yu, Zhou Hong, Zhang Yu-mei, Effect of orally administered bovine colostrum on cytokine production in vivo and in vitro in immunosuppressed mice, International Dairy Journal, 20, 8, 2010. Crossref

  43. Tsuchikawa Takahiro, MD Masaki Miyamoto, Yamamura Yoshiyuki, Shichinohe Toshiaki, Hirano Satoshi, Kondo Satoshi, The Immunological Impact of Neoadjuvant Chemotherapy on the Tumor Microenvironment of Esophageal Squamous Cell Carcinoma, Annals of Surgical Oncology, 19, 5, 2012. Crossref

  44. Fazleabas Asgerally T., Braundmeier Andrea, Parkin Kirstin, Endometriosis-induced changes in regulatory T cells — insights towards developing permanent contraception, Contraception, 92, 2, 2015. Crossref

  45. Sierro Sophie R., Donda Alena, Perret Rachel, Guillaume Philippe, Yagita Hideo, Levy Frédéric, Romero Pedro, Combination of lentivector immunization and low-dose chemotherapy or PD-1/PD-L1 blocking primes self-reactive T cells and induces anti-tumor immunity, European Journal of Immunology, 41, 8, 2011. Crossref

  46. Salem Mohamed L., Abdel Salam Soha G.R., Nassef Mohamed, Hammad Said, El Adl Rania, Immunoenhancing properties of the anti-tumor effects of adoptively transferred T cells with chemotherapeutic cyclophosphamide by co-administration of bone marrow cells, The Journal of Basic & Applied Zoology, 72, 2015. Crossref

  47. Caquard Marylène, Ferret-Bernard Stéphanie, Haurogné Karine, Ouary Michèle, Allard Marie, Jégou Dominique, Bach Jean-Marie, Lieubeau Blandine, Diabetes acceleration by cyclophosphamide in the non-obese diabetic mouse is associated with differentiation of immunosuppressive monocytes into immunostimulatory cells, Immunology Letters, 129, 2, 2010. Crossref

  48. Zheng Yawen, Dou Yan, Duan Lili, Cong Changsheng, Gao Aiqin, Lai Qinghua, Sun Yuping, Using chemo-drugs or irradiation to break immune tolerance and facilitate immunotherapy in solid cancer, Cellular Immunology, 294, 1, 2015. Crossref

  49. O’Reilly Richard J., Dao Tao, Koehne Guenther, Scheinberg David, Doubrovina Ekaterina, Adoptive transfer of unselected or leukemia-reactive T-cells in the treatment of relapse following allogeneic hematopoietic cell transplantation, Seminars in Immunology, 22, 3, 2010. Crossref

  50. Newland Stephen A., Phillips Jenny M., Mastroeni Pietro, Azuma Miyuki, Zaccone Paola, Cooke Anne, PD-L1 blockade overrides Salmonella typhimurium-mediated diabetes prevention in NOD mice: No role for Tregs, European Journal of Immunology, 41, 10, 2011. Crossref

  51. Barbon Christine M., Yang Min, Wands Gregory D., Ramesh Radha, Slusher Barbara S., Hedley Mary Lynne, Luby Thomas M., Consecutive low doses of cyclophosphamide preferentially target Tregs and potentiate T cell responses induced by DNA PLG microparticle immunization, Cellular Immunology, 262, 2, 2010. Crossref

  52. Robson Neil C, Hoves Sabine, Maraskovsky Eugene, Schnurr Max, Presentation of tumour antigens by dendritic cells and challenges faced, Current Opinion in Immunology, 22, 1, 2010. Crossref

  53. Andersen Mads Hald, Junker Niels, Ellebaek Eva, Svane Inge Marie, thor Straten Per, Therapeutic Cancer Vaccines in Combination with Conventional Therapy, Journal of Biomedicine and Biotechnology, 2010, 2010. Crossref

  54. Liu Hua, Three-Dimensional Tumor Model and T-Lymphocytes Immunotherapy for Cancer, in Recent Advances in Cancer Research and Therapy, 2012. Crossref

  55. Rashid Umer, Ansari Farzana L., Challenges in Designing Therapeutic Agents for Treating Alzheimer’s Disease-from Serendipity to Rationality, in Drug Design and Discovery in Alzheimer's Disease, 2014. Crossref

  56. Dantzer Robert, Meagher Mary W., Cleeland Charles S., Translational approaches to treatment-induced symptoms in cancer patients, Nature Reviews Clinical Oncology, 9, 7, 2012. Crossref

  57. Cao Yuchun, Zhao Jie, Yang Zhuoshun, Cai Zaisheng, Zhang Biao, Zhou Yu, Shen Guan-Xin, Chen Xingping, Li Shenqiu, Huang Bo, CD4+FOXP3+ regulatory T cell depletion by low-dose cyclophosphamide prevents recurrence in patients with large condylomata acuminata after laser therapy, Clinical Immunology, 136, 1, 2010. Crossref

  58. Sidana Abhinav, Chowdhury Wasim H., Fuchs Ephraim J., Rodriguez Ronald, Cryoimmunotherapy in Urologic Oncology, Urology, 75, 5, 2010. Crossref

  59. Kozyreva O. V., Novikova E. M., Khatuntseva E. A., Tsvetkov Yu. E., Nifantiev N. E., Stepanenko R. N., Antitumor effect of the conjugate of synthetic carbohydrate moiety of the tumor-associated ganglioside GM3 with hemocyanin in combination with the cytostatic cyclophosphamide, Russian Chemical Bulletin, 63, 6, 2014. Crossref

  60. Sanchez-Perez Luis A., Choi Bryan D., Archer Gary E., Cui Xiuyu, Flores Catherine, Johnson Laura A., Schmittling Robert J., Snyder David, Herndon James E., Bigner Darell D., Mitchell Duane A., Sampson John H., Lesniak Maciej S., Myeloablative Temozolomide Enhances CD8+ T-Cell Responses to Vaccine and Is Required for Efficacy against Brain Tumors in Mice, PLoS ONE, 8, 3, 2013. Crossref

  61. Fuggetta Maria Pia, Lanzilli Giulia, Fioretti Daniela, Rinaldi Monica, In vitroend points for the assessment of cellular immune response-modulating drugs, Expert Opinion on Drug Discovery, 4, 5, 2009. Crossref

  62. Sharabi Amir, Haran-Ghera Nechama, Immune Recovery after Cyclophosphamide Treatment in Multiple Myeloma: Implication for Maintenance Immunotherapy, Bone Marrow Research, 2011, 2011. Crossref

  63. Lotem Michal, Merims Sharon, Frank Stephen, Hamburger Tamar, Nissan Aviram, Kadouri Luna, Cohen Jonathan, Straussman Ravid, Eisenberg Galit, Frankenburg Shoshana, Carmon Einat, Alaiyan Bilal, Shneibaum Shlomo, Ozge Ayyildiz Zeynep, Isbilen Murat, Mert Senses Kerem, Ron Ilan, Steinberg Hanna, Smith Yoav, Shiloni Eitan, Gure Ali Osmay, Peretz Tamar, Adjuvant Autologous Melanoma Vaccine for Macroscopic Stage III Disease: Survival, Biomarkers, and Improved Response to CTLA-4 Blockade, Journal of Immunology Research, 2016, 2016. Crossref

  64. Stakheyeva M., Yunusova N., Patysheva M., Mitrofanova I. V., Faltin V., Tuzikov S., Slonimskaya E., Chemotherapy changes cytotoxic activity of NK-cells in cancer patients, 1882, 2017. Crossref

  65. Aston Wayne J., Hope Danika E., Nowak Anna K., Robinson Bruce W., Lake Richard A., Lesterhuis W. Joost, A systematic investigation of the maximum tolerated dose of cytotoxic chemotherapy with and without supportive care in mice, BMC Cancer, 17, 1, 2017. Crossref

  66. Francisco Neto Aldo, Dell’Armelina Rocha Paulo Ricardo, Perez Elizabeth Christina, Xavier José Guilherme, Peres Giovani Bravin, Spadacci-Morena Diva Denelle, Alvares-Saraiva Anuska Marcelino, Lallo Maria Anete, Marinho Claudio Romero Farias, Diabetes mellitus increases the susceptibility to encephalitozoonosis in mice, PLOS ONE, 12, 11, 2017. Crossref

  67. Shore Neal D., Mantz Constantine A., Dosoretz Daniel E., Fernandez Eduardo, Myslicki Francisco A., Mccoy Candice, Finkelstein Steven Eric, Fishman Mayer N., Building on Sipuleucel-T for Immunologic Treatment of Castration-Resistant Prostate Cancer, Cancer Control, 20, 1, 2013. Crossref

  68. Rasche Leo, Weinhold Niels, Morgan Gareth J., van Rhee Frits, Davies Faith E., Immunologic approaches for the treatment of multiple myeloma, Cancer Treatment Reviews, 55, 2017. Crossref

  69. Huang Cong, Song Kunkun, Ma Wenwen, Ding Jiahui, Chen Zhuo, Zhang Mingmin, Immunomodulatory mechanism of Bushen Huoxue Recipe alleviates cyclophosphamide-induced diminished ovarian reserve in mouse model, Journal of Ethnopharmacology, 208, 2017. Crossref

  70. Gaikwad Sujay, Pawar Yogita, Banerjee Sharmila, Kulkarni Savita, Potential immunomodulatory effect of allelochemical juglone in mice vaccinated with BCG, Toxicon, 157, 2019. Crossref

  71. Park Ho-Young, Oh Mi-Jin, Kim Yoonsook, Choi Inwook, Immunomodulatory activities of Corchorus olitorius leaf extract: Beneficial effects in macrophage and NK cell activation immunosuppressed mice, Journal of Functional Foods, 46, 2018. Crossref

  72. Pereira Mariana Brutschin, Barros Luciana Rodrigues Carvalho, Bracco Paula A., Vigo Alvaro, Boroni Mariana, Bonamino Martín Hernán, Lenz Guido, Transcriptional characterization of immunological infiltrates and their relation with glioblastoma patients overall survival, OncoImmunology, 7, 6, 2018. Crossref

  73. Levy Moshe Yair, Sidana Abhinav, Chowdhury Wasim H., Solomon Steven B., Drake Charles G., Rodriguez Ronald, Fuchs Ephraim J., Cyclophosphamide Unmasks an Antimetastatic Effect of Local Tumor Cryoablation, Journal of Pharmacology and Experimental Therapeutics, 330, 2, 2009. Crossref

  74. Koltai , Cardone , Reshkin , Synergy Between Low Dose Metronomic Chemotherapy and the pH-centered Approach Against Cancer, International Journal of Molecular Sciences, 20, 21, 2019. Crossref

  75. Saida Yu, Watanabe Satoshi, Tanaka Tomohiro, Baba Junko, Sato Ko, Shoji Satoshi, Igarashi Natsue, Kondo Rie, Okajima Masaaki, Koshio Jun, Ichikawa Kosuke, Nozaki Koichiro, Ishikawa Daisuke, Koya Toshiyuki, Miura Satoru, Tanaka Junta, Kagamu Hiroshi, Yoshizawa Hirohisa, Nakata Koh, Narita Ichiei, Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy, The Journal of Immunology, 195, 2, 2015. Crossref

  76. Weis Joachim, Horneber Markus, Etiology and Pathogenesis of Cancer-Related Fatigue, in Cancer-Related Fatigue, 2015. Crossref

  77. Lee Hak Yong, Park Young Mi, Kim Jeong, Oh Hong Geun, Kim Kang Sung, Kang Hee Joo, Kim Ri Rang, Kim Min Jung, Kim Sang Hee, Yang Hye Jeong, Oh Jisun, Orostachys japonicus A. Berger Extracts Induce Immunity-Enhancing Effects on Cyclophosphamide-Treated Immunosuppressed Rats, BioMed Research International, 2019, 2019. Crossref

  78. Dietert Rodney R., Bunn Terry L., Lee Ji-Eun, The Delayed Type Hypersensitivity Assay Using Protein and Xenogeneic Cell Antigens, in Immunotoxicity Testing, 598, 2010. Crossref

  79. Mkrtichyan Mikayel, Najjar Yana G., Raulfs Estella C., Liu Linda, Langerman Solomon, Guittard Geoffrey, Ozbun Laurent, Khleif Samir N., B7-DC-Ig Enhances Vaccine Effect by a Novel Mechanism Dependent on PD-1 Expression Level on T Cell Subsets, The Journal of Immunology, 189, 5, 2012. Crossref

  80. Curiel Tyler J., Managing Regulatory T Cells to Improve Cancer Immunotherapy, in Cancer Immunotherapy, 2013. Crossref

  81. Braun Marion, Perret Rachel, Scholz Godehard, Romero Pedro, Peptide and Protein-Based Cancer Vaccines, in Cancer Immunotherapy, 2013. Crossref

  82. Curiel Tyler J., Regulatory T Cells in Cancer, in Innate Immune Regulation and Cancer Immunotherapy, 2012. Crossref

  83. Boustani , Grapin , Laurent , Apetoh , Mirjolet , The 6th R of Radiobiology: Reactivation of Anti-Tumor Immune Response, Cancers, 11, 6, 2019. Crossref

  84. Jung Il Seon, Jeon Min Gyu, Oh Da Som, Jung Ye Jin, Kim Hyun-Su, Bae Donghyuck, Kim Yujin, Lee Gyeong-eun, Choi Chulyung, Hwang Yong Pil, Micronized, Heat-Treated Lactobacillus plantarum LM1004 Alleviates Cyclophosphamide-Induced Immune Suppression, Journal of Medicinal Food, 22, 9, 2019. Crossref

  85. Meloche Jolyane, Renard Sébastien, Provencher Steeve, Bonnet Sébastien, Anti-inflammatory and Immunosuppressive Agents in PAH, in Pharmacotherapy of Pulmonary Hypertension, 218, 2013. Crossref

  86. Diallo Jean-Simon, Viral Vectors for Treatment of Human Disease: Therapeutic and Manufacturing Challenges, in Nucleic Acid Nanotheranostics, 2019. Crossref

  87. Sarkander Jana, Hojyo Shintaro, Mursell Mathias, Yamasaki Yuzuru, Wu Tsung-Yen, Tumes Damon J., Miyauchi Kosuke, Tran Cam Loan, Zhu Jinfang, Löhning Max, Hutloff Andreas, Mashreghi Mir-Farzin, Kubo Masato, Radbruch Andreas, Tokoyoda Koji, Enhanced Cell Division Is Required for the Generation of Memory CD4 T Cells to Migrate Into Their Proper Location, Frontiers in Immunology, 10, 2020. Crossref

  88. Steinbrink Julie M., Zaas Aimee K., Betancourt Marisol, Modliszewski Jennifer L., Corcoran David L., McClain Micah T., A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states, Translational Research, 219, 2020. Crossref

  89. Murciano-Goroff Yonina R., Warner Allison Betof, Wolchok Jedd D., The future of cancer immunotherapy: microenvironment-targeting combinations, Cell Research, 30, 6, 2020. Crossref

  90. Xie Zhiyong, Dong Wei, Li Zhilian, Chen Yuanhan, Song Li, Li Ruizhao, Wu Yanhua, Fu Lei, Liang Huaban, Tao Yiming, Xie Jianteng, Wang Wenjian, Liu Shuangxin, Ye Zhiming, Shi Wei, Liang Xinling, Clinical value of renal phospholipase A2 receptor deposit in the prognosis evaluation and treatment options of idiopathic membranous nephropathy: A retrospective cohort study, Nephrology, 25, 3, 2020. Crossref

  91. Yang Liwen, Duan Fangfang, Su Danhua, Li Yuehong, Ma Long, Shi Bin, He Xiaoyan, Ma Rui, Ding Chenbo, Sun Suhong, Yao Xinsheng, The effects of CTX damage or inhibition of bone marrow hematopoiesis and GM-CSF stimulation of bone marrow hematopoiesis on the peripheral blood TCRβ CDR3 repertoire of BALB/c mice, Immunopharmacology and Immunotoxicology, 42, 2, 2020. Crossref

  92. Hamilton Gerhard, Avelumab: search for combinations of immune checkpoint inhibition with chemotherapy, Expert Opinion on Biological Therapy, 21, 3, 2021. Crossref

  93. Jang Mi, Lim Tae-Gyu, Lee Eunjung, Hong Hee-Do, Rhee YoungKyoung, Lee YunJi, Lee JeongHoon, Cho Chang-Won, Immunostimulatory activities of a high molecular weight fraction of Cynanchum auriculatum royle ex wight root obtained by ultrafiltration, Pharmacognosy Magazine, 16, 71, 2020. Crossref

  94. Piette Warren W., Broussard-Steinberg Candace M., Hematologic Toxicity of Drug Therapy, in Comprehensive Dermatologic Drug Therapy, 2021. Crossref

  95. Kim Kyeong Jin, Paik Hyun-Dong, Kim Ji Yeon, Immune-Enhancing Effects of Lactobacillus plantarum 200655 Isolated from Korean Kimchi in a Cyclophosphamide-Induced Immunocompromised Mouse Model, Journal of Microbiology and Biotechnology, 31, 5, 2021. Crossref

  96. Song Xinxin, Guo Wenzhong, Cui Jianfeng, Qian Xinlai, Yi Linan, Chang Mengjiao, Cai Qiliang, Zhao Qingzheng, A tritherapy combination of a fusion protein vaccine with immune‐modulating doses of sequential chemotherapies in an optimized regimen completely eradicates large tumors in mice, International Journal of Cancer, 128, 5, 2011. Crossref

  97. Sakthivel Senthilkumar K, Singh Udai P, Singh Shailesh, Taub Dennis D, Novakovic Kristian R, Lillard James W, CXCL10 blockade protects mice from cyclophosphamide-induced cystitis, Journal of Immune Based Therapies and Vaccines, 6, 1, 2008. Crossref

  98. Xie Junhua, Nie Shaoping, Yu Qiang, Yin Junyi, Xiong Tao, Gong Deming, Xie Mingyong, Lactobacillus plantarum NCU116 Attenuates Cyclophosphamide-Induced Immunosuppression and Regulates Th17/Treg Cell Immune Responses in Mice, Journal of Agricultural and Food Chemistry, 64, 6, 2016. Crossref

  99. Krolevets A.A., The properties of nanostructured nitrogen-containing alkylating compounds and their use in the production of functional food products for cancer treatment, Tovaroved prodovolstvennykh tovarov (Commodity specialist of food products), 8, 2021. Crossref

  100. Cook Alistair M., McDonnell Alison, Millward Michael J, Creaney Jenette, Hasani Arman, McMullen Michelle, Meniawy Tarek, Robinson Bruce W.S., Lake Richard a, Nowak Anna K., A phase 1b clinical trial optimizing regulatory T cell depletion in combination with platinum-based chemotherapy in thoracic cancers, Expert Review of Anticancer Therapy, 21, 5, 2021. Crossref

  101. Hirschhorn Daniel, Betof Warner Allison, Maniyar Rachana, Chow Andrew, Mangarin Levi M.B., Cohen Adam D., Hamadene Linda, Rizzuto Gabrielle A., Budhu Sadna, Suek Nathan, Liu Cailian, Houghton Alan N., Merghoub Taha, Wolchok Jedd D., Cyclophosphamide enhances the antitumor potency of GITR engagement by increasing oligoclonal cytotoxic T cell fitness, JCI Insight, 6, 20, 2021. Crossref

  102. Li Yuanyuan, Ma Junguo, Fang Qian, Guo Tingting, Li Xiaoyu, Protective effects of Nostoc sphaeroides Kütz against cyclophosphamide-induced immunosuppression and oxidative stress in mice, Toxin Reviews, 40, 4, 2021. Crossref

  103. Sidana Abhinav, Cancer immunotherapy using tumor cryoablation, Immunotherapy, 6, 1, 2014. Crossref

  104. Kanai Ryuichi, Rabkin Samuel D, Combinatorial strategies for oncolytic herpes simplex virus therapy of brain tumors, CNS Oncology, 2, 2, 2013. Crossref

  105. Elazab Mohamed F. A., Younes Abdelgayed M., Gaafar Alkhateib Y., Abu-Bryka Alaa Z., Abdel-Daim Mohamed M., Immunosuppressive effect of cyclophosphamide in Nile tilapia (Oreochromis niloticus), Environmental Science and Pollution Research, 28, 16, 2021. Crossref

  106. Yin Zhaojun, Chowdhury Sudipa, McKay Craig, Baniel Claire, Wright W. Shea, Bentley Philip, Kaczanowska Katarzyna, Gildersleeve Jeffrey C., Finn M.G., BenMohamed Lbachir, Huang Xuefei, Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-Based Anticancer Vaccine, ACS Chemical Biology, 10, 10, 2015. Crossref

  107. Kaufman Howard L, Bines Steven D, OPTIM trial: a Phase III trial of an oncolytic herpes virus encoding GM-CSF for unresectable stage III or IV melanoma, Future Oncology, 6, 6, 2010. Crossref

  108. George Andrew, Sahin Ilyas, Carneiro Benedito A., Dizon Don S., Safran Howard P., El-Deiry Wafik S., Strategies to sensitize cancer cells to immunotherapy, Human Vaccines & Immunotherapeutics, 17, 8, 2021. Crossref

  109. Chen Jibing, Qian Wei, Mu Feng, Niu Lizhi, Du Duanming, Xu Kecheng, The future of cryoablation: An abscopal effect, Cryobiology, 97, 2020. Crossref

  110. Malvicini Mariana, Rizzo Miguel, Alaniz Laura, Piñero Federico, García Mariana, Atorrasagasti Catalina, Aquino Jorge B., Rozados Viviana, Scharovsky O. Graciela, Matar Pablo, Mazzolini Guillermo, A Novel Synergistic Combination of Cyclophosphamide and Gene Transfer of Interleukin-12 Eradicates Colorectal Carcinoma in Mice, Clinical Cancer Research, 15, 23, 2009. Crossref

  111. Thomas Anish, Rajan Arun, Szabo Eva, Tomita Yusuke, Carter Corey A., Scepura Barbara, Lopez-Chavez Ariel, Lee Min-Jung, Redon Christophe E., Frosch Ari, Peer Cody J., Chen Yuanbin, Piekarz Richard, Steinberg Seth M., Trepel Jane B., Figg William D., Schrump David S., Giaccone Giuseppe, A Phase I/II Trial of Belinostat in Combination with Cisplatin, Doxorubicin, and Cyclophosphamide in Thymic Epithelial Tumors: A Clinical and Translational Study, Clinical Cancer Research, 20, 21, 2014. Crossref

  112. Wang Ji, Li Meihe, Gao Yawen, Li Hongmei, Fang Li, Liu Chunlei, Liu Xiaoting, Min Weihong, Effects of Exopolysaccharides from Lactiplantibacillus plantarum JLAU103 on Intestinal Immune Response, Oxidative Stress, and Microbial Communities in Cyclophosphamide-Induced Immunosuppressed Mice, Journal of Agricultural and Food Chemistry, 70, 7, 2022. Crossref

  113. Remlinger Kathleen A., Hematologic toxicity of drug therapy, in Comprehensive Dermatologic Drug Therapy, 2013. Crossref

  114. Shao Binfen, Huang Xuehui, Xu Funeng, Pan Jingmei, Wang Yi, Zhou Shaobing, A pH-responsive polymersome depleting regulatory T cells and blocking A2A receptor for cancer immunotherapy, Nano Research, 15, 3, 2022. Crossref

  115. Guillaume T, Gaugler B, Chevallier P, Delaunay J, Ayari S, Clavert A, Rialland F, Le Gouill S, Blin N, Gastinne T, Mahé B, Dubruille V, Moreau P, Mohty M, Escalated lymphodepletion followed by donor lymphocyte infusion can induce a graft-versus-host response without overwhelming toxicity, Bone Marrow Transplantation, 47, 8, 2012. Crossref

  116. Delrieu Julien, Vellas Bruno, Drug development and Alzheimer's disease, in Pathy's Principles and Practice of Geriatric Medicine, 2022. Crossref

  117. Hammerbeck Christopher D., Hooper Jay W., T Cells Are Not Required for Pathogenesis in the Syrian Hamster Model of Hantavirus Pulmonary Syndrome, Journal of Virology, 85, 19, 2011. Crossref

  118. Weis Joachim, Quality of Life and Cancer-Related Fatigue: Prevalence, Assessment and Interventions, in Handbook of Quality of Life in Cancer, 2022. Crossref

  119. Lollini Pier-Luigi, De Giovanni Carla, Nanni Patrizia, Immunotherapy, in Cancer Metastasis, 2011. Crossref

  120. Sharabi Amir, Laronne-Bar-On Ayelet, Meshorer Asher, Haran-Ghera Nechama, Chemoimmunotherapy Reduces the Progression of Multiple Myeloma in a Mouse Model, Cancer Prevention Research, 3, 10, 2010. Crossref

  121. Zhao Jie, Cao Yuchun, Lei Zhang, Yang Zhuoshun, Zhang Biao, Huang Bo, Selective Depletion of CD4+CD25+Foxp3+ Regulatory T Cells by Low-Dose Cyclophosphamide Is Explained by Reduced Intracellular ATP Levels, Cancer Research, 70, 12, 2010. Crossref

  122. Sungsuwan Suttipun, Wu Xuanjun, Shaw Vincent, Kavunja Herbert, McFall-Boegeman Hunter, Rashidijahanabad Zahra, Tan Zibin, Lang Shuyao, Tahmasebi Nick Setare, Lin Po-han, Yin Zhaojun, Ramadan Sherif, Jin Xiangshu, Huang Xuefei, Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines, ACS Chemical Biology, 2022. Crossref

  123. Han Hee-Soo, Shin Ji-Sun, Song Young-Ran, Rhee Young Kyoung, Cho Chang-Won, Ryu Jong Hoon, Inn Kyung-Soo, Hong Hee-Do, Lee Kyung-Tae, Immunostimulatory effects of polysaccharides isolated from young barley leaves (Hordeum vulgare L.) with dual activation of Th1 and Th2 in splenic T cells and cyclophosphamide-induced immunosuppressed mice, International Journal of Biological Macromolecules, 147, 2020. Crossref

  124. Li Jun, Li Yuehong, Sun Suhong, Yang Liwen, Ma Long, Shi Bin, Ma Rui, Yao Xinsheng, Characterizing the BCR repertoire during lymphocyte reduction and recovery mediated by cyclophosphamide and granulocyte-macrophage colony-stimulating factor, International Immunopharmacology, 101, 2021. Crossref

  125. Sang Lihong, Li Ji, Zhang Faxing, Jia Jiajia, Zhang Jian, Ding Pingtian, Sun Ting, Wang Dongkai, Glycyrrhetinic acid modified chlorambucil prodrug for hepatocellular carcinoma treatment based on DNA replication and tumor microenvironment, Colloids and Surfaces B: Biointerfaces, 2022. Crossref

2158 Article views 169 Article downloads Metrics
2158 VIEWS 169 DOWNLOADS 125 Crossref CITATIONS Google
Scholar CITATIONS

Articles with similar content:

Targeting OX40 and OX40L for the Treatment of Autoimmunity and Cancer Critical Reviews™ in Immunology, Vol.27, 2007, issue 5
Andrew D. Weinberg, William L. Redmond
CD8+ Memory T Lymphocytes from Bone Marrow— Immune Function and Therapeutic Potential Critical Reviews™ in Immunology, Vol.27, 2007, issue 6
Xiaoyu Zhang, Donna L. Farber, Scott E. Strome, Aaron H. D. Wood
Probiotics in Health and Disease: Distinct Roles of Different Strains in Natural Killer Cell Activation and Regulation Critical Reviews™ in Immunology, Vol.41, 2021, issue 2
Barbara Breznik, Meng-Wei Ko, Yuhao Wang, Nishant Chovatiya, Kawaljit Kaur, Po-Chun Chen, Anahid Jewett, Paul Wong, Emanuela Senjor
The Role of Checkpoint Inhibitors in Autoimmune Diseases: Similarities and Differences Compared with Cancer Critical Reviews™ in Immunology, Vol.42, 2022, issue 3
Meng-Wei Ko, Kawaljit Kaur, Po-Chun Chen, Anahid Jewett
Involvement of Yin Yang 1 (YY1) Expression in T-Cell Subsets Differentiation and Their Functions: Implications in T Cell-Mediated Diseases Critical Reviews™ in Immunology, Vol.39, 2019, issue 6
Feodora Roxanne Kosasih, Benjamin Bonavida

Latest Issue

The Value of Systemic Immune-Inflammation Index and T Cell Subsets in the Severity and Prognosis of Sepsis Hao Zhou MiRNA let-7d-5p Alleviates Inflammatory Responses by Targeting Map3k1 and Inactivating ERK/p38 MAPK Signaling in Microglia Fan Fang, Cheng Chen Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang Effect of the p-Estrogen Receptor at Serine on Its Function and Breast Growth Yuan Liang, Junhui Qin, Tiancheng Ma, Tong Yang, Zhenyu Ke, Ruian Wang

Forthcoming Articles

Identification of key chondrocyte apoptosis-related genes in osteoarthritis based on weighted gene co-expression network analysis and experimental verification Wei Wang, Junyi Hong, Tianyi Cao, Fusheng Ye, Junwei Gao, Shumei Qin Anoikis and Mitophagy-Related Gene Signature for Predicting the Survival and Tumor Cell Progression in Colon Cancer Jian Shen, Minzhe Li Exploring the mechanism of Isoforskolin against asthma based on network pharmacology and experimental verification Yan Fang, Shibo Sun, Chuang Xiao, Min Li, Yuanyuan Zheng, Anju Zu, Zhuang Luo Identification of a novel five-gene prognostic model for laryngeal cancer associated with mitophagy using integrated bioinformatics analysis and experimental verification Dong Song, Lun Dong, Mei Wang, Xiaoping Gao Function of steroid receptor coactivators (SRCs) in T cells and cancers: Implications for cancer immunotherapy Wencan Zhang, Xu Cao, Hongmin Wu, Xiancai Zhong, Yun Shi, Zuoming Sun Electroacupuncture Alleviates Ischemic Stroke by Activating the mTOR/SREBP1 Pathway Jiawang Lang, Jianchang Luo, Luodan Wang, Wenbin Xu, Jie Jia, Zhipeng Zhao, Boxu Lang KIAA1429 induces the m6A modification of LINC01106 to enhance the malignancy of lung adenocarcinoma cell via JAK/STAT3 pathway Di Xu, Ziming Wang, Fajiu Li Mechanistic Insights into Tanshinone IIA in the Amelioration of Post-Thyroidectomy Hypoparathyroidism Xiaoyu Qian, Lin Li, Liang Chen, Chao Shen, Jian Tang MiRNA let-7d-5p alleviates inflammatory responses by targeting Map3k1 and inactivating ERK/p38 MAPK signaling in microglia Fan Fang, Cheng Chen Role of Natural Killer Cells as Cell-Based Immunotherapy in Oral Tumor Eradication and Differentiation Both In Vivo and In Vitro Kawaljit Kaur, Anahid Jewett The Current and Future States of Natural Killer Cell-Based Immunotherapy in Hepatocellular Carcinoma Tu Nguyen, Po-Chun Chen, Janet Pham, Kawaljit Kaur, Steven Raman, Anahid Jewett, Jason Chiang Phillygenin alleviated arthritis through the inhibition of NLRP3 inflammasome and Ferroptosis by AMPK Jianghui Wang, Shufang Ni, Kai Zheng, Yan Zhao, peihong zhang, Hong Chang The value of systemic immune-inflammation index and T cell subsets in the severity and prognosis of sepsis Hao Zhou Efficacy and Nuances of Precision Molecular Engineering for Hodgkin's Disease to a Gene Therapeutic Approach Muhammad Imran Qadir, Bilal Ahmed, Nadir Hussain Serum interleukin 6 and ferritin levels are the independent risk factors for pneumonia in elderly patients Hao Yuan, Jing Tian, Lu Wen Exploration of diagnostic markers associated with inflammation in chronic kidney disease (CKD) based on WGCNA and machine learning Qianjia Wu, Yang Yang, Chongze Lin Clinical significance of serum CTRP3 level in the prediction of cardiac dysfunction and intestinal mucosal barrier dysfunction in patients with severe acute pancreatitis Qiang Shao, Lin Sun The protective effect and mechanism of mild hypothermia on pig lung injury after cardiopulmonary resuscitation Jinlin Ren, Fangfang Zhu, Dongdong Sang, Mulin Cong, Shujuan Jiang Exploring mechanism of Zilongjin in treating lung adenocarcinoma based on network pharmacology combined with experimental verification Kang Zhang, Xiaoqun Chen Gastric Cancer Immune Subtypes and Prognostic Modeling: Insights from Aging-Related Genes Analysis Jian Shen, Minzhe Li Effects of different doses of dexmedetomidine on the prevention of postoperative sleep disturbance and serum neurotransmitter level in patients under general anesthesia Huifei Lu, Fei He, Ying Huang, Zhongliang Wei Identification of key ubiquitination-related genes and their associated with immune infiltration in osteoarthritis based on mRNA-miRNA network Dalu Yuan, Hailiang Shen, Lina Bai, Menglin Li, Qiujie Ye Diagnostic and Prognostic value of peripheral neutrophil CD64 index in elderly patients with community-acquired pneumonia Yan Li, Jing Zhang, Suhang Wang, Jie Cao Identification of Metabolism-Related Prognostic Biomarkers and Immune Features of Head and Neck Squamous Cell Carcinoma Rongjin Zhou, Junguo Wang Downregulation of miR-503-5p promotes the development of pancreatic cancer via targeting cyclin E2 Fei Li, Ying-pei Ling, Pan Wang, Shi-cheng Gu, Hao Jiang, Jie Zhu
Begell Digital Portal Begell Digital Library eBooks Journals References & Proceedings Research Collections Prices and Subscription Policies Begell House Contact Us Language English 中文 Русский Português German French Spain