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Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis

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Abstract

Objective

To clarify the association of IL-6 polymorphisms and periodontitis, a meta-analysis of case-control studies and a systemic review were conducted.

Material and methods

We performed a literature search using PubMed and Medline database to May 2009, with no restrictions. We also reviewed references from all retrieved articles. Six case-control studies involving 1 093 periodontitis cases and 574 controls were selected for meta-analysis to assess the purported associations between IL-6 polymorphisms and the risk of periodontitis. IL-6 −174 G/C and −572 C/G polymorphisms were included in the present meta-analysis, and the association between IL-6 −6331 T/C polymorphism and the risk of periodontitis was adequately reviewed as well.

Results and conclusion

The present meta-analysis indicates that the IL-6 −174 G allele could not modify the risk of chronic periodontitis, but increased the risk of aggressive periodontitis. And −572 C/G polymorphism is associated with the pathogenesis of periodontitis, including chronic periodontitis or aggressive periodontitis.

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  1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, 610041, China

    Mei-ying Shao, Ping Huang, Ran Cheng & Tao Hu

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  1. Mei-ying Shao
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  2. Ping Huang
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  3. Ran Cheng
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  4. Tao Hu
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Correspondence to Tao Hu.

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Shao, My., Huang, P., Cheng, R. et al. Interleukin-6 polymorphisms modify the risk of periodontitis:a systematic review and meta-analysis. J. Zhejiang Univ. Sci. B 10, 920–927 (2009). https://doi.org/10.1631/jzus.B0920279

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