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Complex pathologies of angiotensin II-induced abdominal aortic aneurysms

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Abstract

Angiotensin II (AngII) is the primary bioactive peptide of the renin angiotensin system that plays a critical role in many cardiovascular diseases. Subcutaneous infusion of AngII into mice induces the development of abdominal aortic aneurysms (AAAs). Like human AAAs, AngII-induced AAA tissues exhibit progressive changes and considerable heterogeneity. This complex pathology provides an impediment to the quantification of aneurysmal tissue composition by biochemical and immunostaining techniques. Therefore, while the mouse model of AngII-induced AAAs provides a salutary approach to studying the mechanisms of the evolution of AAAs in humans, meaningful interpretation of mechanisms requires consideration of the heterogeneous nature of the diseased tissue.

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Authors and Affiliations

  1. Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, 40536-0509, USA

    Alan Daugherty & Hong Lu

  2. Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, KY, 40536-0200, USA

    Alan Daugherty & Lisa A. Cassis

Authors
  1. Alan Daugherty
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  2. Lisa A. Cassis
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  3. Hong Lu
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Correspondence to Alan Daugherty.

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Project (Nos. HL062846 and HL80100) supported by the National Institutes of Health of the United States of America

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Daugherty, A., Cassis, L.A. & Lu, H. Complex pathologies of angiotensin II-induced abdominal aortic aneurysms. J. Zhejiang Univ. Sci. B 12, 624–628 (2011). https://doi.org/10.1631/jzus.B1101002

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  • DOI: https://doi.org/10.1631/jzus.B1101002

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