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Daptomycin

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Abstract

  • ▴ Daptomycin is a lipopeptide antibacterial with rapid in vitro activity against Gram-positive cocci. It is approved for use in patients with complicated skin and skin structure infections (cSSSIs) caused by specified Gram-positive cocci.

  • ▴ In vitro, daptomycin was active against Staphylococcus aureus (including meticillin-resistantstrains), Streptococcus pyogenes, S. agalactiae, group C and G β-haemolytic streptococci and vancomycin-susceptible Enterococcus faecalis. Bactericidal activity in vitro was rapid and concentration dependent.

  • ▴ In two randomised, investigator-blinded, multicentre trials in patients with cSSSIs, intravenous daptomycin 4 mg/kg once daily was as effective as standard therapy (intravenous semi-synthetic penicillin 4–12 g/day or vancomycin 1g 12-hourly). Clinical success rates assessed 6–20 days after treatment end were 82.1% in daptomycin recipients and 82.9% in recipients of standard therapy (pooled data).

  • ▴ In patients with cSSSIs, the adverse event profiles of daptomycin and vancomycin were similar. Creatine phosphokinase (CPK) levels increased in 2.8% of daptomycin recipients and 1.8% of patients who received standard therapy; only one daptomycin recipient (0.2%) experienced increased CPK levels and muscle symptoms that were not associated with any comorbid factors.

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  1. Use of tradenames is for product identification purposes only and does not imply endorsement.

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Authors and Affiliations

  1. Adis International Limited, 41 Centorian Drive, Private Bag 65901, Mairangi Bay, Auckland, 1311, New Zealand

    Caroline Fenton, Caroline Fenton, Gillian M. Keating & Monique P. Curran

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  1. Caroline Fenton
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  2. Caroline Fenton
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  3. Gillian M. Keating
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  4. Monique P. Curran
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Correspondence to Caroline Fenton.

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Fenton, C., Fenton, C., Keating, G.M. et al. Daptomycin. Drugs 64, 445–455 (2004). https://doi.org/10.2165/00003495-200464040-00009

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