Abstract
Epigenetic mechanisms play crucial roles in many processes, including neoplasia, genomic imprinting, gene silencing, differentiation, embryogenesis and X chromosome inactivation. Their relevance in human disease and therapy has grown rapidly with the recent emergence of drugs that target for example DNA methylation or histone acetylation. Epigenetic effects were also recently highlighted by the deciphering of the mechanism of action of steroid hormones and anti-hormones acting through nuclear receptors. In this review, we focus on the epigenetic effects associated with long-term treatment of breast cancer cells with the antiestrogen (AE) tamoxifen, in the context of resistance appearance. We summarize the data obtained with a model cell line developed in our laboratory supporting a role for HP1 proteins in the irreversible inactivation of gene expression by long-term treatment with AE.
Keywords: Epigenetic, antiestrogen, tamoxifen, MCF-7, silencing, HP1
Current Medicinal Chemistry
Title: Tamoxifen Resistance and Epigenetic Modifications in Breast Cancer Cell Lines
Volume: 14 Issue: 28
Author(s): Eric Badia, Joan Oliva, Patrick Balaguer and Vincent Cavailles
Affiliation:
Keywords: Epigenetic, antiestrogen, tamoxifen, MCF-7, silencing, HP1
Abstract: Epigenetic mechanisms play crucial roles in many processes, including neoplasia, genomic imprinting, gene silencing, differentiation, embryogenesis and X chromosome inactivation. Their relevance in human disease and therapy has grown rapidly with the recent emergence of drugs that target for example DNA methylation or histone acetylation. Epigenetic effects were also recently highlighted by the deciphering of the mechanism of action of steroid hormones and anti-hormones acting through nuclear receptors. In this review, we focus on the epigenetic effects associated with long-term treatment of breast cancer cells with the antiestrogen (AE) tamoxifen, in the context of resistance appearance. We summarize the data obtained with a model cell line developed in our laboratory supporting a role for HP1 proteins in the irreversible inactivation of gene expression by long-term treatment with AE.
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Cite this article as:
Badia Eric, Oliva Joan, Balaguer Patrick and Cavailles Vincent, Tamoxifen Resistance and Epigenetic Modifications in Breast Cancer Cell Lines, Current Medicinal Chemistry 2007; 14 (28) . https://dx.doi.org/10.2174/092986707782794023
DOI https://dx.doi.org/10.2174/092986707782794023 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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