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Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Endothelium as a Therapeutic Target in Sepsis

Author(s): William C. Aird

Volume 8, Issue 4, 2007

Page: [501 - 507] Pages: 7

DOI: 10.2174/138945007780362782

Price: $65

Abstract

The endothelium plays an important role in health and disease. Endothelial dysfunction contributes to sepsis pathophysiology. An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential.

Keywords: sepsis, Toll-like receptor, macrophage, protease activated receptor, endothelial phenotype, VCAM


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