Abstract
Peripheral blood may be the most feasible tissue source in clinical assessment of differences in gene expression between diseases and drug treatments due to accessibility. Yet, gene expression profiling from blood remains a challenge. Blood is a complicated biological system consisting of a variety of cell types at different stages of development. In addition, blood is also one of the most variable tissue types for gene expression analysis. The success of a blood microarray study depends on the choice of cell isolation method and preparation technique. In this review, we give a brief overview of the current status of using blood as a source for expression profiling and discuss potential applications of this method in the practices of clinical research.
Keywords: blood collection, gene expression profiling
Current Molecular Medicine
Title: The Transcriptome in Blood: Challenges and Solutions for Robust Expression Profiling
Volume: 5 Issue: 1
Author(s): Hongtao Fan and Priti S. Hegde
Affiliation:
Keywords: blood collection, gene expression profiling
Abstract: Peripheral blood may be the most feasible tissue source in clinical assessment of differences in gene expression between diseases and drug treatments due to accessibility. Yet, gene expression profiling from blood remains a challenge. Blood is a complicated biological system consisting of a variety of cell types at different stages of development. In addition, blood is also one of the most variable tissue types for gene expression analysis. The success of a blood microarray study depends on the choice of cell isolation method and preparation technique. In this review, we give a brief overview of the current status of using blood as a source for expression profiling and discuss potential applications of this method in the practices of clinical research.
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Cite this article as:
Fan Hongtao and Hegde S. Priti, The Transcriptome in Blood: Challenges and Solutions for Robust Expression Profiling, Current Molecular Medicine 2005; 5 (1) . https://dx.doi.org/10.2174/1566524053152861
DOI https://dx.doi.org/10.2174/1566524053152861 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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