Generic placeholder image

Current Topics in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

Purine-Scaffold Hsp90 Inhibitors

Author(s): Tony Taldone and Gabriela Chiosis

Volume 9, Issue 15, 2009

Page: [1436 - 1446] Pages: 11

DOI: 10.2174/156802609789895737

Price: $65

Abstract

Hsp90 is a molecular chaperone with important roles in regulating the function of several proteins with potential pathogenic activity. Because many of these proteins are involved in cancer and neurodegenerative promoting pathways, Hsp90 has emerged as an attractive therapeutic target in these diseases. Molecules that bind to the N-terminal nucleotide pocket of Hsp90 inhibit its activity, and consequently, disrupt client protein function. A number of these inhibitors from several chemical classes are now known, and some are already in clinical trials. This review focuses on the purine class of Hsp90 inhibitors, their discovery through rational design, and on efforts aimed towards their optimization and development into clinically viable drugs for the treatment of cancer. Their potential towards neurodegenerative diseases will also be touched upon.

Keywords: Heat shock protein 90, purine, cancer, neurodegeneration


Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy