IMR Press / FBL / Volume 13 / Issue 4 / DOI: 10.2741/2768

Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.

Article
Physical principles of quantitative nuclear magnetic resonance oximetry
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1 Cancer Imaging Program, Department of Radiology, UT Southwestern, Dallas TX
Front. Biosci. (Landmark Ed) 2008, 13(4), 1371–1384; https://doi.org/10.2741/2768
Published: 1 January 2008
Abstract

Over the years many techniques have been devised for the measurement of tissue oxygenation (oximetry). Oximetry using polarographic needle electrodes has long been considered a gold standard. Nuclear Magnetic Resonance (NMR) based oximetry uses exogenously administered reporter molecules such as perfluorocarbons to quantitatively interrogate oxygen tension (pO2). This technique has been successfully used in vivo in the preclinical setting and shows promise for clinical applications. NMR pO2 reporter molecules display a linear dependence of the spin lattice relaxation rate on pO2, which forms the basis of this technique. Physical principles of spin lattice relaxation of pO2 reporter molecules and the pO2 dependence of relaxation rate are discussed in this review. Practical considerations for choice of reporter molecules for in vivo measurements, general methodology and new developments are also described.

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