Frontiers in Bioscience-Landmark (FBL) is published by IMR Press from Volume 26 Issue 5 (2021). Previous articles were published by another publisher on a subscription basis, and they are hosted by IMR Press on imrpress.com as a courtesy and upon agreement with Frontiers in Bioscience.
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Dendritic cells (DCs) are the chief inducers of adaptive immunity. Their normal life cycle begins with the generation of their precursors in the bone-marrow, followed by their release into the blood stream, continues with their entry into non-lymphoid tissues and commences with steady-state or infection-induced migration into draining lymph nodes. Each of these migration steps is controlled by distinct chemokine-chemokine receptor interactions, facilitated by dynamic changes in chemokine receptor expression. In this review, we describe current knowledge on the role of chemokines and their receptors in the control of DC migratory behavior, as well as other influences on DC biology.