Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Kyoichi Adachi; Yoshinobu Matsumori; Tomoo Fujisawa; Tomoari Kamada; Masayasu Kusaka; Tsuneyo Ohumi; Ryuichi Iwakiri; Kanako Yamaguchi; Akiko Danjo; Kazutoshi Hori; Toshihiko Tomita; Takamasa Hayashi; Ken Haruma; Kazuma Fujimoto; Hiroto Miwa; Yoshikazu Kinoshita

doi:10.3164/jcbn.39.46

Original Articles

Symptom Diversity of Patients with Reflux Esophagitis: Effect of Omeprazole Treatment

Kyoichi Adachi, Yoshinobu Matsumori, Tomoo Fujisawa, Tomoari Kamada, Masayasu Kusaka, Tsuneyo Ohumi, Ryuichi Iwakiri, Kanako Yamaguchi, Akiko Danjo, Kazutoshi Hori, Toshihiko Tomita, Takamasa Hayashi, Ken Haruma, Kazuma Fujimoto, Hiroto Miwa, Yoshikazu Kinoshita

Author information

Kyoichi Adachi
Department of Gastroenterology and Hepatology, Shimane University School of Medicine
Yoshinobu Matsumori
Takatsuki General Hospital
Tomoo Fujisawa
Matsue Red Cross Hospital
Tomoari Kamada
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
Masayasu Kusaka
Kusaka Hospital
Tsuneyo Ohumi
Ohumi Clinic
Ryuichi Iwakiri
Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School
Kanako Yamaguchi
Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School
Akiko Danjo
Saga Social Insurance Hospital
Kazutoshi Hori
Department of Internal Medicine, Hyogo College of Medicine
Toshihiko Tomita
Department of Internal Medicine, Hyogo College of Medicine
Takamasa Hayashi
Amagasaki Central Hospital
Ken Haruma
Division of Gastroenterology, Department of Internal Medicine, Kawasaki Medical School
Kazuma Fujimoto
Department of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School
Hiroto Miwa
Department of Internal Medicine, Hyogo College of Medicine
Yoshikazu Kinoshita
Department of Gastroenterology and Hepatology, Shimane University School of Medicine

Keywords: Upper abdominal symptoms, reflux esophagitis, functional dyspepsia, omeprazole

JOURNAL FREE ACCESS

2006 Volume 39 Issue 1 Pages 46-54

DOI https://doi.org/10.3164/jcbn.39.46

Details

Abstract

Objective: A number of clinical trials have reported that proton-pump inhibitors are efficacious in the treatment of upper abdominal symptoms, but most of these trials have been carried out in Caucasians. This study investigated the type of upper abdominal symptoms reported by Japanese patients with reflux esophagitis and the efficacy of omeprazole for treating their symptoms.
Methods: A total of 234 patients aged ≥20 years with grade A to D reflux esophagitis were enrolled in this multicenter, open study. Patients received omeprazole 10 or 20 mg/day for 4 weeks. Symptom and quality of life questionnaires were administered at baseline, week 2 and week 4.
Results: Among the 221 evaluable patients, almost 70% reported reflux-type symptoms (e.g. regurgitation and heartburn). Ulcer- and dysmotility-type symptoms (e.g. stomach pain and belching) were also common, occurring in 38-62% of patients. After 4 weeks of omeprazole treatment, all symptoms (except anorexia) were improved in approximately 90% of patients. Quality of life was also improved following omeprazole treatment.
Conclusion: Reflux-type symptoms as well as ulcer- and dysmotility-type symptoms were seen frequently in Japanese patients with reflux esophagitis. However, omeprazole improved all symptom types and quality of life in this patient population.

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