Supplementing Suckling Rats with Whey Protein Concentrate Modulates the Immune Response and Ameliorates Rat Rotavirus-Induced Diarrhea12
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Abbreviations
AUC
area under the curve
BSA
bovine serum albumin
DPI
day postinoculation
IE
intraepithelial
IEL
intraepithelial lymphocytes
IFN γ
interferon-γ
LF
lactoferrin
FBS
fetal bovine serum
mAb
monoclonal antibody
LSD
least significant difference
NK
natural killer
RV
rotavirus
SIF
standard infant formula
SIF-RV group
rats fed standard infant formula and inoculated with rotavirus
WPC
whey protein concentrate
WPC-RV group
rats fed whey protein concentrate and inoculated with rotavirus
WPC+LF-RV group
rats fed whey protein concentrate and lactoferrin and inoculated with rotavirus
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Supported in part by the Generalitat de Catalunya (SGCR-2005-00833) and Laboratorios Ordesa, S.L. (FBG 302206). The last 2 authors acknowledge partial funding for this research from CIBER Epidemiología y Salud Pública, Spain. S. M. G. was a holder of a fellowship from The University of Barcelona.
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Author disclosures: F. Pérez-Cano, S. Marín-Gallén, M. Castell, M. Rodríguez-Palmero, M. Rivero, C. Castellote, and A. Franch, no conflicts of interest.
Copyright © 2008 American Society for Nutrition. Published by Elsevier Inc. All rights reserved.