CC BY-NC-ND 4.0 · Indian J Plast Surg 2012; 45(01): 109-114
DOI: 10.4103/0970-0358.96599
Original Article
Association of Plastic Surgeons of India

Supplementation of bone marrow aspirate-derived platelet-rich plasma for treating radiation-induced ulcer after cardiac fluoroscopic procedures: A preliminary report

Soh Nishimoto
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
,
Kenji Fukuda
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
,
Kenichiro Kawai
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
,
Toshihiro Fujiwara
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
,
Tomoko Tsumano
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
,
Kazutoshi Fujita
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
,
Masao Kakibuchi
Department of Plastic Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan
› Author Affiliations
Further Information

Publication History

Publication Date:
31 December 2019 (online)

ABSTRACT

Background: The frequency of encountering radiodermatitis caused by X-ray fluoroscopic procedures for ischaemic heart disease is increasing. In severe cases, devastating ulcers with pain, for which conservative therapy is ineffective, emerge. Radiation-induced ulcers are notorious for being difficult to treat. Simple skin grafting often fails because of the poor state of the wound bed. A vascularized flap is a very good option. However, the non-adherence of the well-vascularized flap with the irradiated wound bed is frequently experienced. Aim: To ameliorate the irradiated wound bed, bone marrow-derived platelet-rich plasma (bm-PRP) was delivered during the surgery. Materials and Methods: Four patients with severe cutaneous radiation injury accompanied by unbearable pain after multiple fluoroscopic procedures for ischaemic heart disease were treated. Wide excision of the lesion and coverage with a skin flap supplemented with bm-PRP injection was performed. Results: All patients obtained wound closure and were relieved from pain. No complication concerning the bone marrow aspiration and delivery of bm-PRP was observed. Conclusions: Supplementation of bm-PRP can be an option without major complications, time, and cost to improve the surgical outcome for irradiated wounds.

 
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