Acta Virologica Vol.54, No.1, p.75-78, 2010

Quarterly,
Founded: 1957
ISSN 0001-723X
E-ISSN 1336-2305

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Acta Virologica Vol.54, No.1, p.75-78, 2010
Title: Expression of microRNA-155 precursor in peripheral blood mononuclear cells from hepatitis C patients after antiviral treatment
Author: M. Sidorkiewicz, M. Grek, B. Jozwiak, E. Majda-Stanislawska, A. Piekarska, J. Bartkowiak

Abstract: Chronic hepatitis caused by Hepatitis C virus (HCV) is the main source of liver cirrhosis, hepatocellular carcinoma, and extra-hepatic diseases. After treatment-induced resolution of hepatitis C, the persistence of HCV RNA in serum and peripheral blood mononuclear cells (PBMCs) is often observed. An expression of the precursor of microRNA-155 (miR-155) called BIC can be the factor responsible for a course of HCV infection. Therefore, we assessed the relationship between BIC expression and HCV RNA status in sera and PBMCs samples of 64 hepatitis C patients treated with interferon α (IFN-α) + ribavirin. High expression of BIC in PBMCs was determined in 100% of patients that harbored HCV RNA in serum and PBMCs. Further, we found that 83% of PBMCs samples were BIC-positive in a group of patients that eliminated HCV RNA only from serum. The lowest expression of BIC was found in patients that eliminated HCV RNA from both serum and PBMCs.

Keywords: Hepatitis C virus; microRNA-155; peripheral blood mononuclear cells; BIC; antiviral treatment

Year: 2010, Volume: 54, Issue: 1	Page From: 75, Page To: 78
doi:10.4149/av_2010_01_75
Price: 9.60 €

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