Effects of Pitavastatin on Lipid Profiles and High-Sensitivity CRP in Japanese Subjects with Hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Investigatars

Hiroyuki Koshiyama; Ataru Taniguchi; Kiyoshi Tanaka; Shinji Kagimoto; Yoshio Fujioka; Kenichi Hirata; Yoshio Nakamura; Akane Iwakura; Kyoko Hara; Taizo Yamamoto; Akira Kuroe; Michihiro Ohya; Shimpei Fujimoto; Yoshiyuki Hamamoto; Sachiko Honjo; Hiroki Ikeda; Koichiro Nabe; Kinsuke Tsuda; Nobuya Inagaki; Yutaka Seino; Noriaki Kume

doi:10.5551/jat.E581

Original Articles

Effects of Pitavastatin on Lipid Profiles and High-Sensitivity CRP in Japanese Subjects with Hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) Investigatars

Hiroyuki Koshiyama, Ataru Taniguchi, Kiyoshi Tanaka, Shinji Kagimoto, Yoshio Fujioka, Kenichi Hirata, Yoshio Nakamura, Akane Iwakura, Kyoko Hara, Taizo Yamamoto, Akira Kuroe, Michihiro Ohya, Shimpei Fujimoto, Yoshiyuki Hamamoto, Sachiko Honjo, Hiroki Ikeda, Koichiro Nabe, Kinsuke Tsuda, Nobuya Inagaki, Yutaka Seino, Noriaki Kume

Author information

Hiroyuki Koshiyama
Center for Diabetes & Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital.
Department of Diabetes & Clinical Nutrition, Graduate School of Medicine, Kyoto University.
Ataru Taniguchi
Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital
Kiyoshi Tanaka
Department of Nutrition, Kyoto Women's University
Shinji Kagimoto
Department of Endocrinology and Metabolism, Kamo Hospital.
Yoshio Fujioka
Divison of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine.
Kenichi Hirata
Divison of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine.
Yoshio Nakamura
Division of Diabetes & Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital.
Akane Iwakura
Division of Diabetes & Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital.
Kyoko Hara
Division of Diabetes & Endocrinology, Department of Internal Medicine, Hyogo Prefectural Amagasaki Hospital.
Taizo Yamamoto
Department of Endocrinology and Diabetes, Kyoto-Katsura Hospital.
Akira Kuroe
Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital
Michihiro Ohya
Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital
Shimpei Fujimoto
Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital
Yoshiyuki Hamamoto
Center for Diabetes & Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital.
Department of Diabetes & Clinical Nutrition, Graduate School of Medicine, Kyoto University.
Sachiko Honjo
Center for Diabetes & Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital.
Hiroki Ikeda
Center for Diabetes & Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital.
Koichiro Nabe
Center for Diabetes & Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital.
Kinsuke Tsuda
Graduate School of Human Science, Kyoto University
Nobuya Inagaki
Department of Diabetes & Clinical Nutrition, Graduate School of Medicine, Kyoto University.
Yutaka Seino
Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital
Department of Diabetes & Clinical Nutrition, Graduate School of Medicine, Kyoto University.
Noriaki Kume
Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University.

Keywords: Inflammation, Diabetes, LDL-C, HDL-C

JOURNAL OPEN ACCESS

2008 Volume 15 Issue 6 Pages 345-350

DOI https://doi.org/10.5551/jat.E581

View "Advance Publication" version (December 11, 2008).

Details

Abstract

Aim: The effect of pitavastatin on high-sensitivity C-reactive protein (hs-CRP) has not been reported, yet, in humans. We, therefore, investigated the effects of pitavastatin on lipid profiles and hs-CRP in Japanese subjects with hypercholesterolemia.
Methods: The subjects were 178 Japanese with hypercholesterolemia, including 103 (58%) with type 2 diabetes. Pitavastatin (12 mg/day) was administered for 12 months. Serum low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), remnant-like particle cholesterol (RLP-C), triglycerides (TG) and hs-CRP levels were measured for 12 months.
Results: Serum LDL-C and RLP-C levels were significantly decreased by 30.3% and 22.8%, respectively. Serum TG levels were decreased by 15.9% in subjects with basal TG levels above 150 mg/dl. Serum HDL-C levels were significantly increased. The administration of pitavastatin reduced serum hs-CRP levels by 34.8%. No serious adverse events were observed, including changes in glycosylated hemoglobin levels of diabetic patients.
Conclusion: These results suggest that pitavastatin significantly improves lipid profiles and reduces proinflammatory responses, without adverse effects, in Japanese subjects with hypercholesterolemia, including those with diabetes mellitus.

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