Control of Liposidomycin Production through Precursor-directed Biosynthesis

SHINOBU KAGAMI; YASUAKI ESUMI; MASAMICHI NAKAKOSHI; MAKOTO YOSHIHAMA; KEN-ICHI KIMURA

doi:10.7164/antibiotics.56.552

The Journal of Antibiotics

Online ISSN : 1881-1469
Print ISSN : 0021-8820
ISSN-L : 0021-8820

Control of Liposidomycin Production through Precursor-directed Biosynthesis

SHINOBU KAGAMI, YASUAKI ESUMI, MASAMICHI NAKAKOSHI, MAKOTO YOSHIHAMA, KEN-ICHI KIMURA

Author information

JOURNAL FREE ACCESS

2003 Volume 56 Issue 6 Pages 552-556

DOI https://doi.org/10.7164/antibiotics.56.552

Details

Abstract

Liposidomycin, a potent inhibitor of bacterial peptidoglycan biosynthesis, represents the main component of a group of over 24 closely related, fatty acyl nucleoside antibiotics produced by Streptomyces. Exogeneously supplied myristic acid or palmitic acid resulted in the almost exclusive production of liposidomycin C-(III) and/or M-(III). Exogeneously supplied [1-¹³C]-palmitic acid was incorporated directly into liposidomycin M-(III) as judged by the FAB-MS and ¹³C NMR spectra.

Content from these authors

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!